Melatonin is a signal molecule that modulates the biological circadian rhythms of
vertebrates. Melatonin deficiency is thought to be associated with several disorders …

Melatonin is the primary circadian output signal from the brain and is mainly synthesized in
pinealocytes. The rhythm and secretion of melatonin are under the control of an …

An important role for melatonin in bone formation and restructuring has emerged, and
studies demonstrate the multiple mechanisms for these beneficial actions. Statistical …

Melatonin is known for its regulation of circadian rhythm. Recently, studies have shown that
melatonin may have a positive effect on the skeleton. By increasing age, the melatonin …

Previous studies have revealed that melatonin could play a role in anti-osteoporosis and
promoting osteogenesis. However, the effects of melatonin treatment on osteoporotic bone …

Our understanding of the control of skeletal metabolism has undergone a dynamic shift in
the last two decades, primarily driven by our understanding of energy metabolism. Evidence …

Because the chronobiotic and cytoprotective molecule melatonin diminishes with age, its
involvement in postmenopausal and senescence pathology has been considered since …

Background The protective effect of melatonin against bone metabolism imbalance in
osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. The aim of this …

Melatonin is a neurohormone associated with sleep and wakefulness and is mainly
produced by the pineal gland. Numerous physiological functions of melatonin have been …

Objective Apart from regulating the circadian rhythm, melatonin exerts a variety of actions in
the living organism. Among these functions, melatonin is believed to have a positive effect …