Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Exciting times: new advances towards understanding the regulation and roles of kainate receptors
Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in
regulating neuronal excitability and network function in the brain. After being cloned in the …
regulating neuronal excitability and network function in the brain. After being cloned in the …
LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes
N Sheng, MA Bemben, J Díaz-Alonso… - Proceedings of the …, 2018 - National Acad Sciences
Long-term potentiation (LTP) is a persistent strengthening of synaptic transmission in the
brain and is arguably the most compelling cellular and molecular model for learning and …
brain and is arguably the most compelling cellular and molecular model for learning and …
Neto auxiliary subunits regulate interneuron somatodendritic and presynaptic kainate receptors to control network inhibition
MS Wyeth, KA Pelkey, X Yuan, G Vargish, AD Johnston… - Cell reports, 2017 - cell.com
Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function,
direct evidence for their regulation of native KARs is limited. Because Neto KAR regulation is …
direct evidence for their regulation of native KARs is limited. Because Neto KAR regulation is …
Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Grik1) gene of a genetically audiogenic …
SM Díaz-Rodríguez, MJ Herrero-Turrión… - Frontiers in Molecular …, 2024 - frontiersin.org
Genetic abnormalities affecting glutamate receptors are central to excitatory overload-driven
neuronal mechanisms that culminate in seizures, making them pivotal targets in epilepsy …
neuronal mechanisms that culminate in seizures, making them pivotal targets in epilepsy …
[HTML][HTML] Kainate receptor channel opening and gating mechanism
Kainate receptors, a subclass of ionotropic glutamate receptors, are tetrameric ligand-gated
ion channels that mediate excitatory neurotransmission,,–. Kainate receptors modulate …
ion channels that mediate excitatory neurotransmission,,–. Kainate receptors modulate …
NETO1 guides development of glutamatergic connectivity in the hippocampus by regulating axonal kainate receptors
E Orav, T Atanasova, A Shintyapina, S Kesaf, M Kokko… - eneuro, 2017 - eneuro.org
Kainate-type glutamate receptors (KARs) are highly expressed in the developing brain,
where they are tonically activated to modulate synaptic transmission, network excitability …
where they are tonically activated to modulate synaptic transmission, network excitability …
Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking
N Sheng, YS Shi, RA Nicoll - Proceedings of the National …, 2017 - National Acad Sciences
The kainate receptor (KAR), a subtype of glutamate receptor, mediates excitatory synaptic
responses at a subset of glutamatergic synapses. However, the molecular mechanisms …
responses at a subset of glutamatergic synapses. However, the molecular mechanisms …
Neto2 assembles with kainate receptors in DRG neurons during development and modulates neurite outgrowth in adult sensory neurons
CG Vernon, GT Swanson - Journal of Neuroscience, 2017 - Soc Neuroscience
Peripheral sensory neurons in the dorsal root ganglia (DRG) are the initial transducers of
sensory stimuli, including painful stimuli, from the periphery to central sensory and pain …
sensory stimuli, including painful stimuli, from the periphery to central sensory and pain …
Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain
Kainate-type glutamate receptors play critical roles in excitatory synaptic transmission and
synaptic plasticity in the brain. GluK1 and GluK2 possess fundamentally different capabilities …
synaptic plasticity in the brain. GluK1 and GluK2 possess fundamentally different capabilities …