Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in
regulating neuronal excitability and network function in the brain. After being cloned in the …

Long-term potentiation (LTP) is a persistent strengthening of synaptic transmission in the
brain and is arguably the most compelling cellular and molecular model for learning and …

Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function,
direct evidence for their regulation of native KARs is limited. Because Neto KAR regulation is …

Genetic abnormalities affecting glutamate receptors are central to excitatory overload-driven
neuronal mechanisms that culminate in seizures, making them pivotal targets in epilepsy …

Kainate receptors, a subclass of ionotropic glutamate receptors, are tetrameric ligand-gated
ion channels that mediate excitatory neurotransmission,,–. Kainate receptors modulate …

Kainate-type glutamate receptors (KARs) are highly expressed in the developing brain,
where they are tonically activated to modulate synaptic transmission, network excitability …

The kainate receptor (KAR), a subtype of glutamate receptor, mediates excitatory synaptic
responses at a subset of glutamatergic synapses. However, the molecular mechanisms …

Peripheral sensory neurons in the dorsal root ganglia (DRG) are the initial transducers of
sensory stimuli, including painful stimuli, from the periphery to central sensory and pain …

Kainate-type glutamate receptors play critical roles in excitatory synaptic transmission and
synaptic plasticity in the brain. GluK1 and GluK2 possess fundamentally different capabilities …