Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

The emerging nature of astrocyte diversity

BS Khakh, B Deneen - Annual review of neuroscience, 2019 - annualreviews.org
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …

Calcium signaling in astrocytes and gliotransmitter release

J Goenaga, A Araque, P Kofuji… - Frontiers in synaptic …, 2023 - frontiersin.org
Glia are as numerous in the brain as neurons and widely known to serve supportive roles
such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and …

Implication of cerebral astrocytes in major depression: a review of fine neuroanatomical evidence in humans

LA O'Leary, N Mechawar - Glia, 2021 - Wiley Online Library
Postmortem investigations have implicated astrocytes in many neurological and psychiatric
conditions. Multiple brain regions from individuals with major depressive disorder (MDD) …

Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

N Kalebic, C Gilardi, M Albert, T Namba, KR Long… - Elife, 2018 - elifesciences.org
The evolutionary increase in size and complexity of the primate neocortex is thought to
underlie the higher cognitive abilities of humans. ARHGAP11B is a human-specific gene …

Multicolor multiscale brain imaging with chromatic multiphoton serial microscopy

L Abdeladim, KS Matho, S Clavreul, P Mahou… - Nature …, 2019 - nature.com
Large-scale microscopy approaches are transforming brain imaging, but currently lack
efficient multicolor contrast modalities. We introduce chromatic multiphoton serial (ChroMS) …

Digital reconstruction of the neuro-glia-vascular architecture

E Zisis, D Keller, L Kanari, A Arnaudon… - Cerebral …, 2021 - academic.oup.com
Astrocytes connect the vasculature to neurons mediating the supply of nutrients and
biochemicals. They are involved in a growing number of physiological and …

Anatomy and spatial organization of Müller glia in mouse retina

J Wang, ML O'Sullivan, D Mukherjee… - Journal of …, 2017 - Wiley Online Library
Müller glia, the most abundant glia of vertebrate retina, have an elaborate morphology
characterized by a vertical stalk that spans the retina and branches in each retinal layer …

Assessment of astrocytes as a mediator of memory and learning in rodents

S Akther, H Hirase - Glia, 2022 - Wiley Online Library
The classical view of astrocytes is that they provide supportive functions for neurons,
transporting metabolites and maintaining the homeostasis of the extracellular milieu. This …

Morphometric analysis of astrocytes in brainstem respiratory regions

S SheikhBahaei, B Morris, J Collina… - Journal of …, 2018 - Wiley Online Library
Astrocytes, the most abundant and structurally complex glial cells of the central nervous
system, are proposed to play an important role in modulating the activities of neuronal …