Chemical warfare agents constitute one of the greatest threats in the modern world. Among
them, the neurotoxic agents are of special interest due to their high lethality and danger …

The passage of hydrophilic drugs, such as oxime acetylcholinesterase reactivators, into the
central nervous system is restricted by the blood-brain and the blood-cerebrospinal fluid …

Six chlorinated bispyridinium mono-oximes, analogous to potent charged reactivators K027,
K048, and K203, were synthesized with the aim of improving lipophilicity and reducing the p …

Background Based on in vitro and in vivo rat experiments, the newly developed
acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the …

Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are
useful agents as pesticides, but also represent a serious health hazard. Standard therapy …

Organophosphorus (OP) compounds are highly toxic synthetic compounds which have been
used as pesticides and developed as warfare nerve agents. They represent a threat to both …

Accidental intoxications from environmental pollutants, as well as intentional self‐and
chemical warfare‐related poisonings affect millions of people worldwide each year. While …

This paper reviews the blood–brain barrier (BBB) penetration of newly developed pyridinium
aldoximes. Pyridinium aldoximes are highly charged hydrophilic compounds used in the …

Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide.
Standard therapy with atropine and established oxime-type enzyme reactivators …

Abstract Description of the simple HPLC method with UV detection for the identification of
the acetylcholinesterase reactivator–HI‐6 is described. Two salts of HI‐6 (dichloride and …