The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …

Spontaneous animal behaviour is built from action modules that are concatenated by the
brain into sequences,. However, the neural mechanisms that guide the composition of …

Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain
activity. However, the whole-brain organization of PFC axon projections remains poorly …

The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in
the brain. Revealing its structural and functional organization is critical to understanding …

Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

The basal ganglia are known to influence action selection and modulation of movement
vigor, but whether and how they contribute to specifying the kinematics of learned motor …

Animals make predictions to guide their behavior and update those predictions through
experience. Transient increases in dopamine (DA) are thought to be critical signals for …

INTRODUCTION Psychotic disorders such as schizophrenia impose enormous human,
social, and economic burdens. The prognosis of psychotic disorders has not substantially …

Significant evidence supports the view that dopamine shapes learning by encoding reward
prediction errors. However, it is unknown whether striatal targets receive tailored dopamine …