mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Advances in COVID-19 mRNA vaccine development

E Fang, X Liu, M Li, Z Zhang, L Song, B Zhu… - Signal transduction and …, 2022 - nature.com
To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …

Therapeutic cancer vaccines

M Saxena, SH van der Burg, CJM Melief… - Nature Reviews …, 2021 - nature.com
Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …

mRNA vaccine era—mechanisms, drug platform and clinical prospection

S Xu, K Yang, R Li, L Zhang - International journal of molecular sciences, 2020 - mdpi.com
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …

Dendritic cell biology and its role in tumor immunotherapy

Y Wang, Y Xiang, VW Xin, XW Wang, XC Peng… - Journal of hematology & …, 2020 - Springer
As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor
immunotherapy. Taking into account the many recent advances in DC biology, we discuss …

Emerging concepts and technologies in vaccine development

M Brisse, SM Vrba, N Kirk, Y Liang, H Ly - Frontiers in immunology, 2020 - frontiersin.org
Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused
by pathogens, there are still known diseases and emerging pathogens for which the …

Engineering dendritic cell vaccines to improve cancer immunotherapy

CR Perez, M De Palma - Nature communications, 2019 - nature.com
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play
key roles in tumour immunity and hold a hitherto unrealized potential for cancer …

[HTML][HTML] mRNA vaccines—a new era in vaccinology

N Pardi, MJ Hogan, FW Porter… - Nature reviews Drug …, 2018 - nature.com
Abstract mRNA vaccines represent a promising alternative to conventional vaccine
approaches because of their high potency, capacity for rapid development and potential for …

Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer

Z Ding, Q Li, R Zhang, L Xie, Y Shu, S Gao… - Signal transduction and …, 2021 - nature.com
Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high
tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens …

Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy

T Tang, X Huang, G Zhang, Z Hong, X Bai… - Signal transduction and …, 2021 - nature.com
Despite great success in cancer immunotherapy, immune checkpoint-targeting drugs are not
the most popular weapon in the armory of cancer therapy. Accumulating evidence suggests …