mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
Advances in COVID-19 mRNA vaccine development
E Fang, X Liu, M Li, Z Zhang, L Song, B Zhu… - Signal transduction and …, 2022 - nature.com
To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …
Therapeutic cancer vaccines
M Saxena, SH van der Burg, CJM Melief… - Nature Reviews …, 2021 - nature.com
Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …
understanding of the breadth of tumour-associated antigens, the native immune response …
mRNA vaccine era—mechanisms, drug platform and clinical prospection
S Xu, K Yang, R Li, L Zhang - International journal of molecular sciences, 2020 - mdpi.com
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …
Dendritic cell biology and its role in tumor immunotherapy
Y Wang, Y Xiang, VW Xin, XW Wang, XC Peng… - Journal of hematology & …, 2020 - Springer
As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor
immunotherapy. Taking into account the many recent advances in DC biology, we discuss …
immunotherapy. Taking into account the many recent advances in DC biology, we discuss …
Emerging concepts and technologies in vaccine development
Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused
by pathogens, there are still known diseases and emerging pathogens for which the …
by pathogens, there are still known diseases and emerging pathogens for which the …
Engineering dendritic cell vaccines to improve cancer immunotherapy
CR Perez, M De Palma - Nature communications, 2019 - nature.com
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play
key roles in tumour immunity and hold a hitherto unrealized potential for cancer …
key roles in tumour immunity and hold a hitherto unrealized potential for cancer …
[HTML][HTML] mRNA vaccines—a new era in vaccinology
Abstract mRNA vaccines represent a promising alternative to conventional vaccine
approaches because of their high potency, capacity for rapid development and potential for …
approaches because of their high potency, capacity for rapid development and potential for …
Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer
Z Ding, Q Li, R Zhang, L Xie, Y Shu, S Gao… - Signal transduction and …, 2021 - nature.com
Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high
tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens …
tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens …
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy
T Tang, X Huang, G Zhang, Z Hong, X Bai… - Signal transduction and …, 2021 - nature.com
Despite great success in cancer immunotherapy, immune checkpoint-targeting drugs are not
the most popular weapon in the armory of cancer therapy. Accumulating evidence suggests …
the most popular weapon in the armory of cancer therapy. Accumulating evidence suggests …