A growing body of evidence suggests that plant-associated microorganisms, especially
endophytic and rhizosphere bacteria and fungi, represent a huge and largely untapped …

One of nature's strategies for interfering with molecular interactions is to trap
macromolecules in transition states with their partners in dead-end complexes that are …

The recent advent of robust methods to grow human tissues as 3D organoids allows us to
recapitulate the 3D architecture of tumors in an in vitro setting and offers a new orthogonal …

Small GTP-binding (G) proteins are activated by GDP/GTP nucleotide exchange stimulated
by guanine nucleotide exchange factors (GEFs). Nucleotide dissociation from small G …

Paecilomyces sp. and Aspergillus clavatus, which were isolated from Taxus mairei and
Torreya grandis from southeast China, produced toxic metabolites when grown in liquid …

Endophytic fungi are microorganisms that live inside plant tissues without causing disease
symptoms. In most cases, their relationship with the host plant is considered beneficial …

Endophytic fungi are known to harbour compound (s) beneficial for plant health as well as
human health. Among the metabolites of agrochemical and pharmaceutical importance …

The identification of “druggable” targets is an immediate opportunity and challenge in the
post-genomic era. Natural products are enduring tools for basic cellular studies and leads …

Guanine nucleotide exchange factors (GEFs), which activate small GTP-binding proteins
(SMG) by stimulating their GDP/GTP exchange, are emerging as candidate targets for the …

Ester derivatives of brefeldin A (BFA) were synthesized to determine which of its two
hydroxyl groups could be modified while still maintaining biological activity. The compounds …