Amyloids result from the aggregation of a set of diverse proteins, due to either specific
mutations or promoting intra-or extra-cellular conditions. Structurally, they are rich in …

Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …

Therapeutics designed to target α-synuclein (α-syn) aggregation may be critical in halting
the progression of pathology in Parkinson's disease (PD) patients. Nanobodies are single …

Protein misfolding diseases are caused by the difficulty of a protein to attain or stably
maintain its native three-dimensional structure. In 2011, the first small molecule that …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative
disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn) …

Amyloidosis, commonly known as amyloid-associated diseases, is characterized by
improperly folded proteins accumulating in tissues and eventually causing organ damage …

Following the entry into the host cell, SARS‐CoV‐2 replication is mediated by the replication
transcription complex (RTC) assembled through a number of nonstructural proteins (Nsps) …

Methods that enable the on-demand synthesis of biologically active molecules offer the
potential for a high degree of control over the timing and context of target activation; …

The availability of a genetic model organism with which to study key molecular events
underlying amyloidogenesis is crucial for elucidating the mechanism of the disease and the …

Background Amyloid peptides Aβ40 and Aβ42, whose deposition in brain correlates with
Alzheimer disease, are also present in platelets and have prothrombotic activities. Objective …