Treatment of stress urinary incontinence with muscle stem cells and stem cell components: chances, challenges and future prospects

FA Schmid, JK Williams, TM Kessler, A Stenzl… - International journal of …, 2021 - mdpi.com
Urinary incontinence (UI) is a major problem in health care and more than 400 million
people worldwide suffer from involuntary loss of urine. With an increase in the aging …

Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction

S Shan, Q Li, T Criswell, A Atala, Y Zhang - Cell & Bioscience, 2023 - Springer
Sphincter dysfunction often occurs at the end of tubule organs such as the urethra, anus, or
gastroesophageal sphincters. It is the primary consequence of neuromuscular impairment …

A cocktail of growth factors released from a heparin hyaluronic-acid hydrogel promotes the myogenic potential of human urine-derived stem cells in vivo

G Liu, R Wu, B Yang, Y Shi, C Deng, A Atala, S Mou… - Acta biomaterialia, 2020 - Elsevier
Traditional cell therapy technology relies on the maximum expansion of primary stem cells in
vitro, through multiple passages and potential differentiation protocols, in order to generate …

Regenerative potential of human dental pulp stem cells in the treatment of stress urinary incontinence: In vitro and in vivo study

A Zordani, A Pisciotta, L Bertoni, G Bertani… - Cell …, 2019 - Wiley Online Library
Objectives To evaluate the regenerative potential of human dental pulp stem cells (hDPSCs)
in an animal model of stress urinary incontinence (SUI). SUI, an involuntary leakage of urine …

Mesenchymal stem cell studies in the goat model for biomedical research—A review of the scientific literature

IE Dias, CA Viegas, JF Requicha, MJ Saavedra… - Biology, 2022 - mdpi.com
Simple Summary This review article aims to compile the works published in the scientific
literature, over the last two decades, that use the goat as an animal model in preclinical …

Comprehensive assessment of goat adipose tissue-derived mesenchymal stem cells cultured in different media

M Abraham, I Kori, U Vishwakarma, S Goel - Scientific Reports, 2024 - nature.com
Mesenchymal stem cells (MSCs) have demonstrated potential in treating livestock diseases
that are unresponsive to conventional therapies. MSCs derived from goats, a valuable …

A novel waterjet technology for transurethral cystoscopic injection of viable cells in the urethral sphincter complex

L Jäger, W Linzenbold, A Fech… - Neurourology and …, 2020 - Wiley Online Library
Aims In a recent preclinical study, we noticed that injection of cells in the urethral sphincter
by needle through a cystoscope under visual control frequently yielded in misplacement or …

Application of adipose‐derived, muscle‐derived, and co‐cultured stem cells for the treatment of stress urinary incontinence in rat models

H Jalali Tehrani, SS Daryabari… - LUTS: Lower Urinary …, 2021 - Wiley Online Library
Objectives Based on the recent advancements in cell therapy techniques, we aimed to
evaluate the efficacy of transurethral injection of autologous adipose‐derived stem cells …

Animal models, treatment options, and biomaterials for female stress urinary incontinence

X Tan, G Li, C Li, C Kong, H Li, S Wu - Frontiers in Bioengineering …, 2024 - frontiersin.org
In the quest to tackle stress urinary incontinence (SUI), the synthesis of cutting-edge
biomaterials and regenerative materials has emerged as a promising frontier. Briefly, animal …

Mesenchymal stem cell-based therapy for female stress urinary incontinence

X Liu, T Li, J Zhang, X Lin, W Wang, X Fan… - Frontiers in Cell and …, 2023 - frontiersin.org
Stress urinary incontinence (SUI) adversely affects the quality of life of patients, while the
currently available surgical and non-surgical therapies are not effective in all patients …