Despite the successful development of new therapies for the treatment of type 2 diabetes,
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …

In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence in
the brain of extracellular amyloid-protein (A) and intracellular neurofibrillary tangles …

The persistent increase in the worldwide burden of type 2 diabetes mellitus (T2D) and the
accompanying rise of its complications, including cardiovascular disease, necessitates our …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Background: Antipsychotic-induced metabolic side effects are major concerns in
psychopharmacology and clinical psychiatry. Their pathogenetic mechanisms are still not …

Aims/hypothesis Pancreatic islet beta cell failure causes type 2 diabetes in humans. To
identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for …

Glutamate serves as the dominant central nervous system (CNS) excitatory neurotransmitter,
in part by activating N-methyl-D-aspartate receptors (NMDARs). While the structure, function …

Diabetes is a complex and multifactorial disease that affects millions of people worldwide,
reducing the quality of life significantly, and results in grave consequences for our health …