Psoriatic arthritis is a chronic, immune-mediated, inflammatory arthropathy that presents with
inflammation of the joints and entheses, including those of the axial skeleton, and is …

Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

Macrophages are myeloid immune cells that are strategically positioned throughout the
body tissues, where they ingest and degrade dead cells, debris, and foreign material and …

Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of
rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we …

Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens
and to receive feedback control from adaptive immune cells. Although it was long believed …

Osteoporosis is a major cause of fractures and associated morbidity in the aged population.
The pathogenesis of osteoporosis is multifactorial; whereas traditional pathophysiological …

Osteoclasts (OCLs) are key players in controlling bone remodeling. Modifications in their
differentiation or bone resorbing activity are associated with a number of pathologies …

Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade
bone. Here, we used lineage tracing studies—labelling cells expressing Cx3cr1, Csf1r or …

Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the
engagement of pro-or anti-inflammatory Fcγ receptors (FcγR) and the direction of the …

The mechanisms underlying bone development, repair and regeneration are reliant on the
interplay and communication between osteoclasts and other surrounding cells. Osteoclasts …