The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

The liver is a central regulator of metabolism, and liver failure thus constitutes a major health
burden. Understanding how this complex organ develops during embryogenesis will yield …

WNT signalling has been studied primarily in developing embryos, in which cells respond to
WNTs in a context-dependent manner through changes in survival and proliferation, cell fate …

Recent development of improved tools and methods to analyse tissues at the three-
dimensional level has expanded our capacity to investigate morphogenesis of foetal liver …

Wnt/β‐catenin signaling is emerging as a forerunner for its critical roles in many facets of
human biology. Its roles in embryogenesis, organogenesis, and maintaining tissue and …

Liver development requires two linked processes: differentiation of the various hepatic cell
types from their embryonic progenitors and the arrangement of those cells into structures …

The liver and pancreas arise from a common multipotent population of endoderm cells and
share many aspects of their early development. Yet each tissue originates from multiple …

The study of liver development has significantly contributed to developmental concepts
about morphogenesis and differentiation of other organs. Knowledge of the mechanisms …

The combined use of genetic manipulation in mice and advanced culturing techniques,
along with the availability of model genetic systems, underlies the recent expansion in our …

Hepatocellular carcinoma is often diagnosed at an advanced stage, when it is not amenable
to curative therapies. There is no effective chemotherapy. Advances in cancer biology …