All cells in the human body are covered by a dense layer of sugars and the proteins and
lipids to which they are attached, collectively termed the “glycocalyx.” For decades, the …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Carbohydrates, which are ubiquitously distributed throughout the three domains of life, play
significant roles in a variety of vital biological processes. Access to unique and …

High acidity and structural confinement are pivotal elements in asymmetric acid catalysis.
The recently introduced imidodiphosphorimidate (IDPi) Brønsted acids have met with …

The metabolic heterogeneity and metabolic interplay between cells are known as significant
contributors to disease treatment resistance. However, with the lack of a mature high …

Glycosylation is a chemical transformation that is centrally important in all glycoscience and
related technologies. Catalysts offering good control over reactivity and selectivity in …

The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable.
We have developed a database of acceptor nucleophilic constants (Aka) to quantify the …

C (sp3)–H and C (sp2)–H glycosylations of structurally complex amino acids and peptides
were accomplished through the assistance of triazole peptide-isosteres. The palladium …

Mucins are a highly glycosylated protein family that are secreted by animals for adhesion,
hydration, lubrication, and other functions. Despite their ubiquity, animal mucins are largely …

Polysaccharides comprise a diverse class of polymeric materials with a history of proven
biocompatibility and continual use as biomaterials. Recent focus on new matrices …