Amyloid structures as biofilm matrix scaffolds

A Taglialegna, I Lasa, J Valle - Journal of bacteriology, 2016 - Am Soc Microbiol
Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward
the recognition of amyloid fibers as common building block structures that confer stability to …

Curli-containing enteric biofilms inside and out: matrix composition, immune recognition, and disease implications

SA Tursi, Ç Tükel - Microbiology and Molecular Biology Reviews, 2018 - Am Soc Microbiol
Biofilms of enteric bacteria are highly complex, with multiple components that interact to
fortify the biofilm matrix. Within biofilms of enteric bacteria such as Escherichia coli and …

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

TR Sampson, C Challis, N Jain, A Moiseyenko… - elife, 2020 - elifesciences.org
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases …

Dynamic biofilm architecture confers individual and collective mechanisms of viral protection

L Vidakovic, PK Singh, R Hartmann, CD Nadell… - Nature …, 2018 - nature.com
In nature, bacteria primarily live in surface-attached, multicellular communities, termed
biofilms,,,,–. In medical settings, biofilms cause devastating damage during chronic and …

Programmable biofilm-based materials from engineered curli nanofibres

PQ Nguyen, Z Botyanszki, PKR Tay, NS Joshi - Nature communications, 2014 - nature.com
The significant role of biofilms in pathogenicity has spurred research into preventing their
formation and promoting their disruption, resulting in overlooked opportunities to develop …

Structural analysis and architectural principles of the bacterial amyloid curli

M Sleutel, B Pradhan, AN Volkov, H Remaut - Nature Communications, 2023 - nature.com
Two decades have passed since the initial proposition that amyloids are not only (toxic)
byproducts of an unintended aggregation cascade, but that they can also be produced by an …

Staphylococcal Bap proteins build amyloid scaffold biofilm matrices in response to environmental signals

A Taglialegna, S Navarro, S Ventura, JA Garnett… - PLoS …, 2016 - journals.plos.org
Biofilms are communities of bacteria that grow encased in an extracellular matrix that often
contains proteins. The spatial organization and the molecular interactions between matrix …

The green tea polyphenol EGCG inhibits E. coli biofilm formation by impairing amyloid curli fibre assembly and downregulating the biofilm regulator CsgD via the σE …

DO Serra, F Mika, AM Richter… - Molecular …, 2016 - Wiley Online Library
In bacterial biofilms, which are often involved in chronic infections, cells are surrounded by a
self‐produced extracellular matrix that contains amyloid fibres, exopolysaccharides and …

Sum of the parts: composition and architecture of the bacterial extracellular matrix

OA McCrate, X Zhou, C Reichhardt… - Journal of molecular …, 2013 - Elsevier
Bacterial biofilms are complex multicellular assemblies that exhibit resistance to antibiotics
and contribute to the pathogenesis of serious and chronic infectious diseases. New …

Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli

SA Tursi, RD Puligedda, P Szabo, LK Nicastro… - Nature …, 2020 - nature.com
Bacterial biofilms, especially those associated with implanted medical devices, are difficult to
eradicate. Curli amyloid fibers are important components of the biofilms formed by the …