Amyloid structures as biofilm matrix scaffolds
Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward
the recognition of amyloid fibers as common building block structures that confer stability to …
the recognition of amyloid fibers as common building block structures that confer stability to …
Curli-containing enteric biofilms inside and out: matrix composition, immune recognition, and disease implications
SA Tursi, Ç Tükel - Microbiology and Molecular Biology Reviews, 2018 - Am Soc Microbiol
Biofilms of enteric bacteria are highly complex, with multiple components that interact to
fortify the biofilm matrix. Within biofilms of enteric bacteria such as Escherichia coli and …
fortify the biofilm matrix. Within biofilms of enteric bacteria such as Escherichia coli and …
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases …
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases …
Dynamic biofilm architecture confers individual and collective mechanisms of viral protection
In nature, bacteria primarily live in surface-attached, multicellular communities, termed
biofilms,,,,–. In medical settings, biofilms cause devastating damage during chronic and …
biofilms,,,,–. In medical settings, biofilms cause devastating damage during chronic and …
Programmable biofilm-based materials from engineered curli nanofibres
The significant role of biofilms in pathogenicity has spurred research into preventing their
formation and promoting their disruption, resulting in overlooked opportunities to develop …
formation and promoting their disruption, resulting in overlooked opportunities to develop …
Structural analysis and architectural principles of the bacterial amyloid curli
Two decades have passed since the initial proposition that amyloids are not only (toxic)
byproducts of an unintended aggregation cascade, but that they can also be produced by an …
byproducts of an unintended aggregation cascade, but that they can also be produced by an …
Staphylococcal Bap proteins build amyloid scaffold biofilm matrices in response to environmental signals
Biofilms are communities of bacteria that grow encased in an extracellular matrix that often
contains proteins. The spatial organization and the molecular interactions between matrix …
contains proteins. The spatial organization and the molecular interactions between matrix …
The green tea polyphenol EGCG inhibits E. coli biofilm formation by impairing amyloid curli fibre assembly and downregulating the biofilm regulator CsgD via the σE …
DO Serra, F Mika, AM Richter… - Molecular …, 2016 - Wiley Online Library
In bacterial biofilms, which are often involved in chronic infections, cells are surrounded by a
self‐produced extracellular matrix that contains amyloid fibres, exopolysaccharides and …
self‐produced extracellular matrix that contains amyloid fibres, exopolysaccharides and …
Sum of the parts: composition and architecture of the bacterial extracellular matrix
OA McCrate, X Zhou, C Reichhardt… - Journal of molecular …, 2013 - Elsevier
Bacterial biofilms are complex multicellular assemblies that exhibit resistance to antibiotics
and contribute to the pathogenesis of serious and chronic infectious diseases. New …
and contribute to the pathogenesis of serious and chronic infectious diseases. New …
Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli
SA Tursi, RD Puligedda, P Szabo, LK Nicastro… - Nature …, 2020 - nature.com
Bacterial biofilms, especially those associated with implanted medical devices, are difficult to
eradicate. Curli amyloid fibers are important components of the biofilms formed by the …
eradicate. Curli amyloid fibers are important components of the biofilms formed by the …