The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Abstract The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder originally described
by Dr. Alfred Wiskott in 1937 and Dr. Robert Aldrich in 1954 as a familial disease …

ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as
nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives …

The filamentous meshwork formed by the lamin nucleoskeleton provides a scaffold for the
anchoring of highly condensed heterochromatic DNA to the nuclear envelope, thereby …

The intracellular bacteria Legionella pneumophila encodes a type IV secretion system
(T4SS) that injects effector proteins into macrophages in order to establish and replicate …

Currently, cancer metastases remain a major clinical problem that highlights the importance
of recognition of the metastatic process in cancer diagnosis and treatment. A critical process …

Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR)
causes genomic instability. Genomic instability occurs in Wiskott-Aldrich syndrome (WAS), a …

Abstract The Wiskott–Aldrich syndrome protein (WASP) participates in innate and adaptive
immunity through regulation of actin cytoskeleton‐dependent cellular processes, including …

Immunoactinopathies caused by mutations in actin‐related proteins are a growing group of
inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin …

Wiskott–Aldrich syndrome is a life-threatening primary immunodeficiency associated with a
bleeding tendency, eczema and a high incidence of autoimmunity and malignancy. Stem …