Cytomegalovirus latency and reactivation: an intricate interplay with the host immune response
CMV is an ancient herpesvirus that has co-evolved with its host over millions of years. The
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …
The human cytomegalovirus decathlon: Ten critical replication events provide opportunities for restriction
DL Turner, RA Mathias - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Human cytomegalovirus (HCMV) is a ubiquitous human pathogen that can cause severe
disease in immunocompromised individuals, transplant recipients, and to the developing …
disease in immunocompromised individuals, transplant recipients, and to the developing …
Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB
JF Santana, GS Collins, M Parida, DS Luse… - Nucleic acids …, 2022 - academic.oup.com
The effects of rapid acute depletion of components of RNA polymerase II (Pol II) general
transcription factors (GTFs) that are thought to be critical for formation of preinitiation …
transcription factors (GTFs) that are thought to be critical for formation of preinitiation …
Differences in RNA polymerase II complexes and their interactions with surrounding chromatin on human and cytomegalovirus genomes
Interactions of the RNA polymerase II (Pol II) preinitiation complex (PIC) and paused early
elongation complexes with the first downstream (+ 1) nucleosome are thought to be …
elongation complexes with the first downstream (+ 1) nucleosome are thought to be …
Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II
Herpesvirus late promoters activate gene expression after viral DNA synthesis has begun.
Alphaherpesviruses utilize a viral immediate-early protein to do this, whereas beta-and …
Alphaherpesviruses utilize a viral immediate-early protein to do this, whereas beta-and …
Human cytomegalovirus long noncoding RNA4. 9 regulates viral DNA replication
J Tai-Schmiedel, S Karniely, B Lau, A Ezra… - PLoS …, 2020 - journals.plos.org
Viruses are known for their extremely compact genomes composed almost entirely of protein-
coding genes. Nonetheless, four long noncoding RNAs (lncRNAs) are encoded by human …
coding genes. Nonetheless, four long noncoding RNAs (lncRNAs) are encoded by human …
A unified view of the sequence and functional organization of the human RNA polymerase II promoter
To better understand human RNA polymerase II (Pol II) promoters in the context of promoter-
proximal pausing and local chromatin organization, 5′ and 3′ ends of nascent capped …
proximal pausing and local chromatin organization, 5′ and 3′ ends of nascent capped …
Human cytomegalovirus infection elicits global changes in host transcription by RNA polymerases I, II, and III
How human cytomegalovirus (HCMV) infection impacts the transcription of the host genome
remains incompletely understood. Here, we examine the global consequences of infection …
remains incompletely understood. Here, we examine the global consequences of infection …
Comprehensive annotations of human herpesvirus 6A and 6B genomes reveal novel and conserved genomic features
Y Finkel, D Schmiedel, J Tai-Schmiedel, A Nachshon… - Elife, 2020 - elifesciences.org
Human herpesvirus-6 (HHV-6) A and B are ubiquitous betaherpesviruses, infecting the
majority of the human population. They encompass large genomes and our understanding …
majority of the human population. They encompass large genomes and our understanding …
HSV-1 infection induces a downstream shift of promoter-proximal pausing for host genes
E Weiß, T Hennig, P Graßl, L Djakovic… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT Herpes simplex virus 1 (HSV-1) infection exerts a profound shutoff of host gene
expression at multiple levels. Recently, HSV-1 infection was reported to also impact …
expression at multiple levels. Recently, HSV-1 infection was reported to also impact …