CMV is an ancient herpesvirus that has co-evolved with its host over millions of years. The
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …

Human cytomegalovirus (HCMV) is a ubiquitous human pathogen that can cause severe
disease in immunocompromised individuals, transplant recipients, and to the developing …

The effects of rapid acute depletion of components of RNA polymerase II (Pol II) general
transcription factors (GTFs) that are thought to be critical for formation of preinitiation …

Interactions of the RNA polymerase II (Pol II) preinitiation complex (PIC) and paused early
elongation complexes with the first downstream (+ 1) nucleosome are thought to be …

Herpesvirus late promoters activate gene expression after viral DNA synthesis has begun.
Alphaherpesviruses utilize a viral immediate-early protein to do this, whereas beta-and …

Viruses are known for their extremely compact genomes composed almost entirely of protein-
coding genes. Nonetheless, four long noncoding RNAs (lncRNAs) are encoded by human …

To better understand human RNA polymerase II (Pol II) promoters in the context of promoter-
proximal pausing and local chromatin organization, 5′ and 3′ ends of nascent capped …

How human cytomegalovirus (HCMV) infection impacts the transcription of the host genome
remains incompletely understood. Here, we examine the global consequences of infection …

Human herpesvirus-6 (HHV-6) A and B are ubiquitous betaherpesviruses, infecting the
majority of the human population. They encompass large genomes and our understanding …

ABSTRACT Herpes simplex virus 1 (HSV-1) infection exerts a profound shutoff of host gene
expression at multiple levels. Recently, HSV-1 infection was reported to also impact …