Genomes are more than linear sequences. In vivo they exist as elaborate physical
structures, and their functional properties are strongly determined by their cellular …

The vast diversity of cellular types and behaviours is mainly the result of combinatorial
interactions between a limited number of transcription factors and cellular signalling …

Laminopathies, caused by mutations in the LMNA gene encoding the nuclear envelope
proteins lamins A and C, represent a diverse group of diseases that include Emery–Dreifuss …

Poly (ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme that is rapidly activated by
DNA strand breaks and signals the presence of DNA lesions by attaching ADP-ribose units …

In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell
surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to …

Besides its essential and well established role as a component of the cytoskeleton, actin is
also present in the cell nucleus, where it has been linked to many processes that control …

Metastasis causes death of 90% of cancer patients, so it is the most significant issue
associated with cancer disease. Thus, it is no surprise that many researchers are trying to …

Nuclear actin has been implicated in a variety of DNA-related processes including chromatin
remodeling, transcription, replication, and DNA repair. However, the mechanistic …

Female meiosis in higher organisms consists of highly asymmetric divisions, which retain
most maternal stores in the oocyte for embryo development. Asymmetric partitioning of the …

The actin cytoskeleton is one of the major structural components of the cell. It often
undergoes rapid reorganization and plays crucial roles in a number of dynamic cellular …