Biosynthesis and signalling functions of central and peripheral nervous system neurosteroids in health and disease
E Lloyd-Evans, H Waller-Evans - Essays in Biochemistry, 2020 - portlandpress.com
Neurosteroids are steroid hormones synthesised de novo in the brain and peripheral
nervous tissues. In contrast to adrenal steroid hormones that act on intracellular nuclear …
nervous tissues. In contrast to adrenal steroid hormones that act on intracellular nuclear …
Neuroactive steroids: receptor interactions and responses
Neuroactive steroids (NASs) are naturally occurring steroids, which are synthesized
centrally as de novo from cholesterol and are classified as pregnane, androstane, and …
centrally as de novo from cholesterol and are classified as pregnane, androstane, and …
Gonadotropin-inhibitory hormone (GnIH): A new key neurohormone controlling reproductive physiology and behavior
K Tsutsui, T Ubuka - Frontiers in Neuroendocrinology, 2021 - Elsevier
The discovery of novel neurohormones is important for the advancement of
neuroendocrinology. In early 1970s, gonadotropin-releasing hormone (GnRH), a …
neuroendocrinology. In early 1970s, gonadotropin-releasing hormone (GnRH), a …
Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits
gonadotropin secretion and socio-sexual behaviours. Oestrogen (neuroestrogen) …
gonadotropin secretion and socio-sexual behaviours. Oestrogen (neuroestrogen) …
Contribution of GnIH research to the progress of reproductive neuroendocrinology
K Tsutsui, T Ubuka, YL Son, GE Bentley… - Frontiers in …, 2015 - frontiersin.org
Since the discovery of gonadotropin-releasing hormone (GnRH) in mammals at the
beginning of the 1970s, it was generally accepted that GnRH is the only hypothalamic …
beginning of the 1970s, it was generally accepted that GnRH is the only hypothalamic …
How to contribute to the progress of neuroendocrinology: discovery of GnIH and progress of GnIH research
K Tsutsui, T Ubuka - Frontiers in endocrinology, 2018 - frontiersin.org
It is essential to discover novel neuropeptides that regulate the functions of pituitary, brain
and peripheral secretory glands for the progress of neuroendocrinology. Gonadotropin …
and peripheral secretory glands for the progress of neuroendocrinology. Gonadotropin …
[HTML][HTML] Discovery of gonadotropin-inhibitory hormone (GnIH), progress in GnIH research on reproductive physiology and behavior and perspective of GnIH research …
K Tsutsui, T Ubuka - Molecular and Cellular Endocrinology, 2020 - Elsevier
Based on extensive studies on gonadotropin-releasing hormone (GnRH) it was assumed
that GnRH is the only hypothalamic neurohormone regulating gonadotropin release in …
that GnRH is the only hypothalamic neurohormone regulating gonadotropin release in …
Nongenomic actions of neurosteroid pregnenolone and its metabolites
JH Weng, B Chung - Steroids, 2016 - Elsevier
Steroids have been widely used in the clinical setting. They bind and activate nuclear
receptors to regulate gene expression. In addition to activating genomic transcription …
receptors to regulate gene expression. In addition to activating genomic transcription …
Neuropeptidergic control of neurosteroids biosynthesis
T Ubuka, K Tsutsui - Frontiers in Neuroendocrinology, 2022 - Elsevier
Neurosteroids are steroids synthesized within the central nervous system either from
cholesterol or by metabolic reactions of circulating steroid hormone precursors. It has been …
cholesterol or by metabolic reactions of circulating steroid hormone precursors. It has been …
De novo synthesized estradiol: a role in modulating the cerebellar function
The estrogen estradiol is a potent neuroactive steroid that may regulate brain structure and
function. Although the effects of estradiol have been historically associated with gonadal …
function. Although the effects of estradiol have been historically associated with gonadal …