Importance Osteoarthritis (OA) is the most common joint disease, affecting an estimated
more than 240 million people worldwide, including an estimated more than 32 million in the …

Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to
manage this disease. However, the current standard of care does not provide satisfactory …

OBJECTIVE: In an effort to evolve semi-quantitative scoring methods based upon limitations
identified in existing tools, integrating expert readers' experience with all available scoring …

Background The methods for assessing knee osteoarthritis (OA) do not provide enough
comprehensive information to make robust and accurate outcome predictions. Purpose To …

Prevention is an attractive solution for the staggering and increasingly unmanageable
burden of osteoarthritis. Despite this, the field of osteoarthritis prevention is relatively …

Background Osteoarthritis is generally a slowly progressive disorder. However, at least 1 in
7 people with incident knee osteoarthritis develop an abrupt progression to advanced-stage …

Osteoarthritis (OA) is a highly prevalent chronic condition with marked implications for
affected individuals and public health care. There are available treatments to manage pain …

Objective Pain sensitization is associated with pain severity in knee osteoarthritis (OA), but
its cause in humans is not well understood. We examined whether inflammation, assessed …

Objective To evaluate the efficacy and safety of intraarticular sprifermin (recombinant human
fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA). Methods …

Recent years have seen tremendous progress towards therapy of many previously incurable
neuromuscular diseases. This new context has acted as a driving force for the development …