An updated review of the H19 lncRNA in human cancer: molecular mechanism and diagnostic and therapeutic importance
Accumulating evidence has reported that H19 long non-coding RNA (lncRNA) expression
level is deregulated in human cancer. It has been also demonstrated that de-regulated …
level is deregulated in human cancer. It has been also demonstrated that de-regulated …
RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression
KA Cohen-Solal, RK Boregowda, A Lasfar - Molecular cancer, 2015 - Springer
From the first reported role of the transcription factor RUNX2 in osteoblast and chondrocyte
differentiation and migration to its involvement in promigratory/proinvasive behavior of …
differentiation and migration to its involvement in promigratory/proinvasive behavior of …
Inhibition of Bcl-2 synergistically enhances the antileukemic activity of midostaurin and gilteritinib in preclinical models of FLT3-mutated acute myeloid leukemia
J Ma, S Zhao, X Qiao, T Knight, H Edwards, L Polin… - Clinical Cancer …, 2019 - AACR
Purpose: To investigate the efficacy of the combination of the FLT3 inhibitors midostaurin or
gilteritinib with the Bcl-2 inhibitor venetoclax in FLT3-internal tandem duplication (ITD) acute …
gilteritinib with the Bcl-2 inhibitor venetoclax in FLT3-internal tandem duplication (ITD) acute …
Runt-related transcription factor 1 (RUNX1) promotes TGF-β-induced renal tubular epithelial-to-mesenchymal transition (EMT) and renal fibrosis through the PI3K …
T Zhou, M Luo, W Cai, S Zhou, D Feng, C Xu… - …, 2018 - thelancet.com
Renal fibrosis is widely considered a common mechanism leading to end-stage renal
failure. Epithelial-to-mesenchymal transition (EMT) plays important roles in the pathogenesis …
failure. Epithelial-to-mesenchymal transition (EMT) plays important roles in the pathogenesis …
Binding of released Bim to Mcl-1 is a mechanism of intrinsic resistance to ABT-199 which can be overcome by combination with daunorubicin or cytarabine in AML …
Purpose: To investigate the molecular mechanism underlying intrinsic resistance to ABT-
199. Experimental Design: Western blots and real-time RT-PCR were used to determine …
199. Experimental Design: Western blots and real-time RT-PCR were used to determine …
Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells
DA Luedtke, X Niu, Y Pan, J Zhao, S Liu… - Signal transduction and …, 2017 - nature.com
Acute myeloid leukemia (AML) is a serious disease. The 5-year survival rates remain
frustratingly low (65% for children and 26% for adults). Resistance to frontline chemotherapy …
frustratingly low (65% for children and 26% for adults). Resistance to frontline chemotherapy …
The biology of pediatric acute megakaryoblastic leukemia
TA Gruber, JR Downing - Blood, The Journal of the American …, 2015 - ashpublications.org
Acute megakaryoblastic leukemia (AMKL) comprises between 4% and 15% of newly
diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down …
diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down …
[HTML][HTML] Long noncoding RNA H19-derived miR-675 enhances proliferation and invasion via RUNX1 in gastric cancer cells
G Liu, T Xiang, QF Wu, WX Wang - Oncology research, 2016 - ncbi.nlm.nih.gov
The lncRNA H19 and its mature product miR-675 have recently been shown to be
upregulated and promote the progression of gastric cancer. However, the detailed function …
upregulated and promote the progression of gastric cancer. However, the detailed function …
Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases
M Rada, A Kapelanski-Lamoureux, S Petrillo… - Communications …, 2021 - nature.com
Colorectal cancer liver metastasis (CRCLM) has two major histopathological growth
patterns: angiogenic desmoplastic and non-angiogenic replacement. The replacement …
patterns: angiogenic desmoplastic and non-angiogenic replacement. The replacement …
Haematopoietic development and leukaemia in D own syndrome
I Roberts, S Izraeli - British journal of haematology, 2014 - Wiley Online Library
Children with constitutional trisomy 21 (cT 21, D own S yndrome, DS) are at a higher risk for
both myeloid and B‐lymphoid leukaemias. The myeloid leukaemias are often preceded by a …
both myeloid and B‐lymphoid leukaemias. The myeloid leukaemias are often preceded by a …