Context Theory and simulation suggest that randomized controlled trials (RCTs) stopped
early for benefit (truncated RCTs) systematically overestimate treatment effects for the …

The acute respiratory distress syndrome (ARDS) is a frequent, life-threatening disease in
which a marked increase in alveolar surface tension has been repeatedly observed. It is …

Corona virus SARS-CoV-2 has already spread around the whole world and is currently, with
no vaccine available yet, unstoppable. As per today, COVID-19 affects more than 3,000,000 …

Type I and type II pneumocytes are two forms of epithelial cells found lining the alveoli in the
lungs. Type II pneumocytes exclusively secrete 'pulmonary surfactants,'a lipoprotein …

Lung alveolar type-II (AT-II) cells produce pulmonary surfactant (PS), consisting of proteins
and lipids. The lipids in PS are primarily responsible for reducing the air-fluid surface tension …

Respiratory failure secondary to surfactant deficiency is a major cause of morbidity and
mortality in preterm infants. Surfactant therapy substantially reduces mortality and respiratory …

We compared the onset of clinical response and safety of two surfactants, poractant alfa
(Curosurf, Chiesi Pharmaceuticals, Parma, Italy) and beractant (Survanta, Ross …

Langmuir monolayers have provided experimentally accessible models for studies of lung
surfactants at the air-alveolus interface since the medical necessity of lung surfactant was …

Background A wide variety of surfactant preparations have been developed and tested
including synthetic surfactants and surfactants derived from animal sources. Although …

OBJECTIVES: To address issues about data monitoring committees (DMCs) for randomised
controlled trials (RCTs). DATA SOURCES: Electronic databases. Handsearching of selected …