[HTML][HTML] Copper metabolism as a unique vulnerability in cancer

VC Shanbhag, N Gudekar, K Jasmer… - … et Biophysica Acta (BBA …, 2021 - Elsevier
The last 25 years have witnessed tremendous progress in identifying and characterizing
proteins that regulate the uptake, intracellular trafficking and export of copper. Although …

Etiology of metabolic syndrome and dietary intervention

H Xu, X Li, H Adams, K Kubena, S Guo - International journal of molecular …, 2018 - mdpi.com
The growing prevalence of metabolic syndrome (MetS) in the US and even worldwide is
becoming a serious health problem and economic burden. MetS has become a crucial risk …

The molecular and cellular basis of copper dysregulation and its relationship with human pathologies

MT Maung, A Carlson, M Olea‐Flores… - The FASEB …, 2021 - Wiley Online Library
Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

Defining the human copper proteome and analysis of its expression variation in cancers

S Blockhuys, E Celauro, C Hildesjö, A Feizi, O Stål… - Metallomics, 2017 - academic.oup.com
Copper (Cu) is essential for living organisms, and acts as a cofactor in many metabolic
enzymes. To avoid the toxicity of free Cu, organisms have specific transport systems that …

Profiling maternal plasma microRNA expression in early pregnancy to predict gestational diabetes mellitus

Y Zhu, F Tian, H Li, Y Zhou, J Lu, Q Ge - International Journal of …, 2015 - Elsevier
Objective To profile the differential expression of plasma miRNAs in gestational diabetes
mellitus (GDM). Methods In a pilot study conducted at a tertiary hospital in China between …

Copper homeostasis and cuproptosis in tumor pathogenesis and therapeutic strategies

C Bian, Z Zheng, J Su, S Chang, H Yu, J Bao… - Frontiers in …, 2023 - frontiersin.org
Copper is an indispensable micronutrient for the development and replication of all
eukaryotes, and its redox properties are both harmful and beneficial to cells. An imbalance …

[HTML][HTML] Genetic prediction of male pattern baldness

SP Hagenaars, WD Hill, SE Harris, SJ Ritchie… - PLoS …, 2017 - journals.plos.org
Male pattern baldness can have substantial psychosocial effects, and it has been
phenotypically linked to adverse health outcomes such as prostate cancer and …

IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights

H Li, IS Batth, X Qu, L Xu, N Song, R Wang, Y Liu - Molecular cancer, 2017 - Springer
The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition
(EMT) program and contributes to metastasis and drug resistance in several subtypes of …

Memo is a copper-dependent redox protein with an essential role in migration and metastasis

G MacDonald, I Nalvarte, T Smirnova, M Vecchi… - Science …, 2014 - science.org
Memo is an evolutionarily conserved protein with a critical role in cell motility. We found that
Memo was required for migration and invasion of breast cancer cells in vitro and …

The emerging role of insulin and insulin-like growth factor signaling in cancer stem cells

R Malaguarnera, A Belfiore - Frontiers in endocrinology, 2014 - frontiersin.org
Cancer cells frequently exploit the IGF signaling, a fundamental pathway mediating
development, cell growth, and survival. As a consequence, several components of the IGF …