[HTML][HTML] Biological effects of radiation on cancer cells
J Wang, H Wang, H Qian - Military medical research, 2018 - Springer
With the development of radiotherapeutic oncology, computer technology and medical
imaging technology, radiation therapy has made great progress. Research on the impact …
imaging technology, radiation therapy has made great progress. Research on the impact …
[HTML][HTML] Hypoxia in solid tumors: how low oxygenation impacts the “Six Rs” of radiotherapy
Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …
[HTML][HTML] Hypoxia-induced cancer cell responses driving radioresistance of hypoxic tumors: approaches to targeting and radiosensitizing
AE Kabakov, AO Yakimova - Cancers, 2021 - mdpi.com
Simple Summary Some regions of aggressive malignancies experience hypoxia due to
inadequate blood supply. Cancer cells adapting to hypoxic conditions somehow become …
inadequate blood supply. Cancer cells adapting to hypoxic conditions somehow become …
Molecular targeting of hypoxia in radiotherapy
Hypoxia (low O 2) is an essential microenvironmental driver of phenotypic diversity in
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …
Advances in histone demethylase KDM4 as cancer therapeutic targets
DH Lee, GW Kim, YH Jeon, J Yoo, SW Lee… - The FASEB …, 2020 - Wiley Online Library
Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …
[HTML][HTML] Hypoxia-regulated target genes implicated in tumor metastasis
YP Tsai, KJ Wu - Journal of biomedical science, 2012 - Springer
Hypoxia is an important microenvironmental factor that induces cancer metastasis.
Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the …
Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the …
[HTML][HTML] Cell cycle progression in response to oxygen levels
Hypoxia ‚or decreases in oxygen availability ‚results in the activation of a number of different
responses at both the whole organism and the cellular level. These responses include …
responses at both the whole organism and the cellular level. These responses include …
JMJD2B promotes epithelial–mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis
L Zhao, W Li, W Zang, Z Liu, X Xu, H Yu, Q Yang… - Clinical Cancer …, 2013 - AACR
Purpose: This study investigated the role of histone demethylase Jumonji domain–
containing protein 2B (JMJD2B) in promoting epithelial–mesenchymal transition (EMT) and …
containing protein 2B (JMJD2B) in promoting epithelial–mesenchymal transition (EMT) and …
[HTML][HTML] Tumour response to hypoxia: understanding the hypoxic tumour microenvironment to improve treatment outcome in solid tumours
KJA Bigos, CG Quiles, S Lunj, DJ Smith… - Frontiers in …, 2024 - frontiersin.org
Hypoxia is a common feature of solid tumours affecting their biology and response to
therapy. One of the main transcription factors activated by hypoxia is hypoxia-inducible …
therapy. One of the main transcription factors activated by hypoxia is hypoxia-inducible …
[HTML][HTML] KDM4B: a nail for every hammer?
C Wilson, AJ Krieg - Genes, 2019 - mdpi.com
Epigenetic changes are well-established contributors to cancer progression and normal
developmental processes. The reversible modification of histones plays a central role in …
developmental processes. The reversible modification of histones plays a central role in …