With the development of radiotherapeutic oncology, computer technology and medical
imaging technology, radiation therapy has made great progress. Research on the impact …

Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …

Simple Summary Some regions of aggressive malignancies experience hypoxia due to
inadequate blood supply. Cancer cells adapting to hypoxic conditions somehow become …

Hypoxia (low O 2) is an essential microenvironmental driver of phenotypic diversity in
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Hypoxia is an important microenvironmental factor that induces cancer metastasis.
Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the …

Hypoxia ‚or decreases in oxygen availability ‚results in the activation of a number of different
responses at both the whole organism and the cellular level. These responses include …

Purpose: This study investigated the role of histone demethylase Jumonji domain–
containing protein 2B (JMJD2B) in promoting epithelial–mesenchymal transition (EMT) and …

Hypoxia is a common feature of solid tumours affecting their biology and response to
therapy. One of the main transcription factors activated by hypoxia is hypoxia-inducible …

Epigenetic changes are well-established contributors to cancer progression and normal
developmental processes. The reversible modification of histones plays a central role in …