Antecedentes Esta la segunda actualización de una revisión publicada anteriormente en la
Biblioteca Cochrane (2015, primera actualización en 2017). La interleucina 5 (IL‐5) es la …

Asthma is one of the most common chronic immunological diseases in humans, affecting
people from childhood to old age. Progress in treating asthma has been relatively slow and …

Background Asthma is a respiratory (airway) condition that affects an estimated 300 million
people worldwide and is associated with significant morbidity and mortality. Omalizumab is …

The incidence and severity of chronic lung diseases is growing and affects between 100 and
150 million people worldwide and is associated with a significant rate of mortality …

Recent developments in therapeutic strategies have provided alternatives to corticosteroids
as the cornerstone treatment for managing airway inflammation in asthma. The past two …

Decades of research in animal models have provided abundant evidence to show that IL-13
is a key TH2 cytokine that directs many of the important features of airway inflammation and …

Interleukin-13 is a pleiotropic TH2 cytokine that has been shown to be central to the
pathogenesis of asthma. Some of the most prominent of the effects of IL-13 include …

Abstract IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different
cell types and responsible for a broad range of biology and functions. Physiologically, Th2 …

Improving the lung function after experimental allergen challenge by blocking of mast cell
(MC) mediators and the capability of MC mediators (including histamine, prostaglandin (PG) …

Biologic agents (also termed biologicals or biologics) are therapeutics that are synthesized
by living organisms and directed against a specific determinant, for example, a cytokine or …