Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are elucidated as
cells that can perpetuate themselves via autorestoration. These cells are highly resistant to …

Antagonism of protein–protein interactions (PPIs) with small molecules is becoming more
feasible as a therapeutic approach. Successful PPI inhibitors tend to target proteins …

The proliferative and invasive nature of malignant cancers drives lethality. In glioblastoma,
these two processes are presumed mutually exclusive and hence termed “go or grow.” We …

Cell-division cycle protein 20 homologue (Cdc20) has important functions in chromosome
segregation and mitotic exit. Cdc20 is the target of the spindle assembly checkpoint (SAC) …

Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein
ligase that targets different substrates for ubiquitylation and therefore regulates a variety of …

Aneuploidy is a very rare and tissue‐specific event in normal conditions, occurring in a low
number of brain and liver cells. Its frequency increases in age‐related disorders and is one …

Aberrant expression of cell division cycle 20 (CDC20) is associated with malignant
progression and poor prognosis in various types of cancer. The development of specific …

PRMT6, a type I arginine methyltransferase, di-methylates the arginine residues of both
histones and non-histones asymmetrically. Increasing evidence indicates that PRMT6 plays …

Glioma stem cells (GSCs) have a central role in glioblastoma (GBM) development and
chemo/radiation resistance, and their elimination is critical for the development of efficient …

A stem-like subpopulation existed in GBM cells, called glioma stem cells (GSCs), might
contribute to cancer invasion, angiogenesis, immune evasion, and therapeutic resistance …