Bringing immunofocusing into focus
Immunofocusing is a strategy to create immunogens that redirect humoral immune
responses towards a targeted epitope and away from non-desirable epitopes …
responses towards a targeted epitope and away from non-desirable epitopes …
Stabilized trimeric peptide immunogens of the complete HIV-1 gp41 N-heptad repeat and their use as HIV-1 vaccine candidates
C Wu, IT Raheem, DD Nahas… - Proceedings of the …, 2024 - National Acad Sciences
Efforts to develop an HIV-1 vaccine include those focusing on conserved structural elements
as the target of broadly neutralizing monoclonal antibodies. MAb D5 binds to a highly …
as the target of broadly neutralizing monoclonal antibodies. MAb D5 binds to a highly …
[HTML][HTML] Alpaca-derived nanobody targeting the hydrophobic pocket of the HIV-1 gp41 NHR broadly neutralizes HIV-1 by blocking six-helix bundle formation
L Sun, B Chen, X Liu, Y Zhu, G Zhang, X Liang… - Current Research in …, 2024 - Elsevier
The highly conserved hydrophobic pocket region of HIV-1 gp41 NHR triple-stranded coiled
coil is crucial for the binding of CHR to NHR to form a six-helix bundle (6-HB). This pocket is …
coil is crucial for the binding of CHR to NHR to form a six-helix bundle (6-HB). This pocket is …