Resistance to TKIs in EGFR-mutated non-small cell lung cancer: from mechanisms to new therapeutic strategies
Simple Summary Resistance to tyrosine kinase inhibitors (TKIs) of the epidermal growth
factor receptor (EGFR) in advanced mutant non-small cell lung cancer (NSCLC) constitutes …
factor receptor (EGFR) in advanced mutant non-small cell lung cancer (NSCLC) constitutes …
Small molecule kinase inhibitors for the treatment of brain cancer
TP Heffron - Journal of medicinal chemistry, 2016 - ACS Publications
In addition to each of the factors that govern the identification of a successful oncology drug
candidate, drug discovery aimed at treating neurological cancer must also consider the …
candidate, drug discovery aimed at treating neurological cancer must also consider the …
Lung cancer in the Indian subcontinent
Smoking tobacco, both cigarettes and beedis, is the principal risk factor for causation of lung
cancer in Indian men; however, among Indian women, the association with smoking is not …
cancer in Indian men; however, among Indian women, the association with smoking is not …
[HTML][HTML] MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer
C Wei, R Zhang, Q Cai, X Gao, F Tong, J Dong… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
Brain metastasis (BM) is associated with poor prognosis in patients with non-small cell lung
cancer (NSCLC). We sought to identify microRNAs (miRNAs) that could serve as biomarkers …
cancer (NSCLC). We sought to identify microRNAs (miRNAs) that could serve as biomarkers …
[HTML][HTML] Hype or hope–Can combination therapies with third-generation EGFR-TKIs help overcome acquired resistance and improve outcomes in EGFR-mutant …
F Papini, J Sundaresan, A Leonetti, M Tiseo… - Critical Reviews in …, 2021 - Elsevier
Three generations of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-
TKIs) have been developed for treating advanced/metastatic non-small cell lung cancer …
TKIs) have been developed for treating advanced/metastatic non-small cell lung cancer …
Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer
MY Baek, HK Ahn, KR Park, HS Park… - The Korean journal …, 2016 - pmc.ncbi.nlm.nih.gov
Background/Aims We investigated the time taken for patients with metastatic non-small cell
lung cancer (NSCLC) to develop brain metastases (BM), as well as their subsequent overall …
lung cancer (NSCLC) to develop brain metastases (BM), as well as their subsequent overall …
First-line afatinib for the treatment of EGFR mutation-positive non-small-cell lung cancer in the 'real-world' clinical setting
K Park, D Wan-Teck Lim, I Okamoto… - … advances in medical …, 2019 - journals.sagepub.com
Afatinib is an ErbB family blocker that is approved for the treatment of epidermal growth
factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC). Pivotal …
factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC). Pivotal …
[HTML][HTML] Clinical outcome of tyrosine kinase inhibitors alone or combined with radiotherapy for brain metastases from epidermal growth factor receptor (EGFR) mutant …
Q Zhu, Y Sun, Y Cui, K Ye, C Yang, D Yang, J Ma… - Oncotarget, 2017 - ncbi.nlm.nih.gov
This study compared treatment outcomes between TKI monotherapy and TKI administration
combined with brain radiotherapy (TKI+ RT) in 133 non-small cell lung cancer (NSCLC) …
combined with brain radiotherapy (TKI+ RT) in 133 non-small cell lung cancer (NSCLC) …
Impact of metastatic status on the prognosis of EGFR mutation‑positive non‑small cell lung cancer patients treated with first‑generation EGFR‑tyrosine kinase inhibitors
Y Taniguchi, A Tamiya, K Nakahama… - Oncology …, 2017 - spandidos-publications.com
The aim of the present study was to analyze the impact of metastatic status on the prognosis
of epithelial growth factor receptor (EGFR) mutation‑positive patients with non‑small cell …
of epithelial growth factor receptor (EGFR) mutation‑positive patients with non‑small cell …
[PDF][PDF] Lung cancer in India: Current status and promising strategies
PM Parikh, AA Ranade, B Govind… - South Asian journal …, 2016 - thieme-connect.com
Lung cancer is a leading cause of death globally. It is also a major healthcare problem in
India.[1] An online search using the words “lung cancer India” yielded the following hits on …
India.[1] An online search using the words “lung cancer India” yielded the following hits on …