Myeloid neoplasms include myeloproliferative and myelodysplastic neoplasms and acute
myeloid leukaemia. Historically, these diseases have been diagnosed based on …

The field of cancer genomics and transcriptomics has evolved from targeted profiling to swift
sequencing of individual tumor genome and transcriptome. The steady growth in genome …

Cytokine release syndrome (CRS) is the most common complication of chimeric antigen
receptor redirected T cells (CAR-T) therapy. CAR-T toxicity management has been greatly …

Simple Summary Structural genetic variants, such as gene fusions, are frequently detected
in hematologic neoplasias. Over the past few decades, these structural variants have gained …

NUP98, a nuclear pore complex component, functions as abnormal transcription factor in
fusion proteins, and its partner genes in NUP98 fusions also possess transcription-related …

Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic
malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA …

Subtyping of acute myeloid leukaemia (AML) is predominantly based on recurrent genetic
abnormalities, but recent literature indicates that transcriptomic phenotyping holds immense …

Unlike genomic alterations, gene expression profiles have not been widely used to refine
cancer therapies. We analyzed transcriptional changes in acute myeloid leukemia (AML) …

Introduction Defining the chromosomal and molecular changes associated with myeloid
neoplasms (MNs) optimizes clinical care through improved diagnosis, prognosis, treatment …

The current classification of acute myeloid leukemia (AML) relies largely on genomic
alterations. AML with mutated nucleophosmin 1 (NPM1-mut) is the largest of the genetically …