Cancer is a life-threatening concern worldwide. Sensitive and early-stage diagnostics of
different cancer types can make it possible for patients to get through the best available …

The unique ability to adapt and thrive in inhospitable, stressful tumor microenvironments
(TME) also renders cancer cells resistant to traditional chemotherapeutic treatments and/or …

Extracellular vesicles (EVs) have emerged as a potential biomarker in liquid biopsy.
However, cancer heterogeneity poses significant challenge to precise molecular diagnosis …

Cellular prion protein (PrPC) is highly expressed in a variety of tumor cells and plays a
crucial role in neurodegenerative diseases. Its N-terminal domain contains a conserved …

Cell-SELEX is a powerful tool to generate aptamers that specifically bind the native
molecules on living cells. Here, we report an aptamer ZAJ4a generated by cell-SELEX. The …

Circular aptamers are promising candidates for analytical and therapeutic applications due
to their enhanced biological and structural stability. However, the process of circular aptamer …

As a kind of recognition molecule, aptamers can be inserted into some regulatory
sequences for the smart response of their targets. However, the molecular engineering …

Selection of targeted and efficient carriers to deliver drugs and genes to cells and tissues is
still a major challenge and to overcome this obstacle, aptamers conjugated to nanoparticles …

Aptamers are functional oligonucleotide acids that are generated by an in vitro directed
evolved technique termed as SELEX to specifically recognize specific targets with high …

In this chapter we will introduce the general concept of aptamers, their types, and general
characteristics which makes them an attractive agent in the modern diagnosis, bioimaging …