Bradykinin-related peptides, the kinins, are blood-derived peptides that stimulate 2 G protein–
coupled receptors, the B 1 and B 2 receptors (B 1 R, B 2 R). The pharmacologic and …

G-protein coupled receptors (GPCRs) are seven transmembrane receptors that are pivotal
regulators of cellular responses including vision, cardiac contractility, olfaction, and platelet …

Key points Rat somatosensory neurons express a junctional protein, junctophilin‐4 (JPH4)
JPH4 is necessary for the formation of store operated Ca2+ entry (SOCE) complex at the …

We here report the discovery and early characterization of Compound 3, a representative of
a novel class of small molecule bradykinin (BK) B2 receptor antagonists, and its superior …

Kinins are the small and fragile hydrophilic peptides related to bradykinin (BK) and derived
from circulating kininogens via the action of kallikreins. Kinins bind to the preformed and …

Objective Determine the effect of bradykinin on solute permeability and cellular junctional
proteins in human dermis microvascular endothelial cells. Methods Cells were characterized …

Βradykinin stimulation of B2 receptor is known to activate the oncogenic ERK pathway and
overexpression of bradykinin receptors B1 and B2 has been reported to occur in glioma …

Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from
blood. We applied various forms of activation to fresh blood obtained from 10 healthy …

The blood vessels are one of the important target tissues for the mediators of inflammation
and allergy; further cytokines affect them in a number of ways. We review the use of the …

Maximakinin, a 19-residue peptide from the amphibian Bombina maxima, incorporates the
full sequence of bradykinin (BK) at its C-terminus with a hydrophilic 10-residue N-terminal …