Cell shape and forces in elastic and structured environments: from single cells to organoids
R Link, K Weißenbruch, M Tanaka… - Advanced Functional …, 2024 - Wiley Online Library
With the advent of mechanobiology, cell shape and forces have emerged as essential
elements of cell behavior and fate, in addition to biochemical factors such as growth factors …
elements of cell behavior and fate, in addition to biochemical factors such as growth factors …
Printed Electronic Devices and Systems for Interfacing with Single Cells up to Organoids
The field of bioelectronics with the aim to contact cells, cell clusters, biological tissues and
organoids has become a vast enterprise. Currently, it is mainly relying on classical micro …
organoids has become a vast enterprise. Currently, it is mainly relying on classical micro …
[HTML][HTML] Cingulin and paracingulin tether myosins-2 to junctions to mechanoregulate the plasma membrane
The mechanisms that regulate the spatial sorting of nonmuscle myosins-2 (NM2) isoforms
and couple them mechanically to the plasma membrane are unclear. Here we show that the …
and couple them mechanically to the plasma membrane are unclear. Here we show that the …
S100A11 promotes focal adhesion disassembly via myosin II-driven contractility and Piezo1-mediated Ca2+ entry
TO Mohammed, YR Lin, L Akter… - Journal of Cell …, 2024 - journals.biologists.com
ABSTRACT S100A11 is a small Ca2+-activatable protein known to localize along stress
fibers (SFs). Analyzing S100A11 localization in HeLa and U2OS cells further revealed …
fibers (SFs). Analyzing S100A11 localization in HeLa and U2OS cells further revealed …
Lack of skeletal muscle contraction disrupts fibrous tissue morphogenesis in the developing murine knee
TK Tsinman, Y Huang, S Ahmed… - Journal of …, 2023 - Wiley Online Library
Externally applied forces, such as those generated through skeletal muscle contraction, are
important to embryonic joint formation, and their loss can result in gross morphologic defects …
important to embryonic joint formation, and their loss can result in gross morphologic defects …
Cell size and actin architecture determine force generation in optogenetically activated cells
T Andersen, D Wörthmüller, D Probst, I Wang… - Biophysical …, 2023 - cell.com
Adherent cells use actomyosin contractility to generate mechanical force and to sense the
physical properties of their environment, with dramatic consequences for migration, division …
physical properties of their environment, with dramatic consequences for migration, division …
[HTML][HTML] Engines of change: Nonmuscle myosin II in mechanobiology
M Garrido-Casado, G Asensio-Juárez… - Current Opinion in Cell …, 2024 - Elsevier
The emergence of mechanobiology has unveiled complex mechanisms by which cells
adjust intracellular force production to their needs. Most communicable intracellular forces …
adjust intracellular force production to their needs. Most communicable intracellular forces …
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division
F Kage, M Vicente-Manzanares… - Molecular Biology of …, 2022 - Am Soc Cell Biol
The formin INF2 polymerizes a calcium-activated cytoplasmic network of actin filaments,
which we refer to as calcium-induced actin polymerization (CIA). CIA plays important roles in …
which we refer to as calcium-induced actin polymerization (CIA). CIA plays important roles in …
[HTML][HTML] Theory of active self-organization of dense nematic structures in the actin cytoskeleton
The actin cytoskeleton is remarkably adaptable and multifunctional. It often organizes into
nematic bundles such as contractile rings or stress fibers. However, how a uniform and …
nematic bundles such as contractile rings or stress fibers. However, how a uniform and …
Effect of empagliflozin on cytoskeletal repair in the hippocampus of obese mice
X Chen, L Ma, J Zhao, X Pan, S Chen - Frontiers in Neuroscience, 2022 - frontiersin.org
Objective We aimed to investigate the effect of empagliflozin on hippocampal
phosphorylated protein levels in obese mice. Materials and methods Sixteen obese mice …
phosphorylated protein levels in obese mice. Materials and methods Sixteen obese mice …