Inadequate perioperative pain is, unfortunately, frequent, and has clinically relevant
consequences, including decreased patient satisfaction, delayed postoperative mobilization …

Surgical procedures are key drivers of pain development and opioid utilization globally.
Various organizations have generated guidance on postoperative pain management …

There is an epidemic of opioid use, abuse, and misuse in the United States, which results in
significant morbidity and mortality. It may be difficult to reduce perioperative opioid use given …

Importance Guidelines recommend using gabapentin to decrease postoperative pain and
opioid use, but significant variation exists in clinical practice. Objective To determine the …

Importance The use of gabapentinoids in multimodal postoperative analgesia is increasing;
however, when coadministered with opioids, these drugs may potentiate central nervous …

Introduction: The first two alpha2delta ligands–gabapentin (GBP) and pregabalin (PGB)–
were initially synthesized as antiepileptics; however, they were later also found to be useful …

The focus of perioperative pain management should be to attempt to minimise the
nociceptive input and reduce the risk of transition to central sensitisation. Gabapentinoids …

BACKGROUND: Gabapentinoids are widely used in perioperative multimodal analgesic
regimens. The primary aim of this study was to determine whether gabapentin was …

Introduction: There are various important implications associated with poorly controlled
postoperative pain in the adult surgical patient–this includes cardiopulmonary …

Surgical care episodes place opioid-naïve patients at risk for transitioning to new persistent
postoperative opioid use. With one of the central principles being the application of …