An adrenal incidentaloma is now established as a common endocrine diagnosis that
requires a multidisciplinary approach for effective management. The majority of patients can …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

Aldosterone-producing adenoma (APA) cause primary aldosteronism—the most frequent
form of secondary hypertension. Somatic mutations in genes coding for ion channels and …

Endogenous Cushing's syndrome results from excess glucocorticoid secretion, which leads
to a myriad of clinical manifestations, comorbidities, and increased mortality despite …

Aldosterone and cortisol, the main mineralocorticoid and glucocorticoid hormones in
humans, are produced in the adrenal cortex, which is composed of three concentric zones …

Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone
disorder adrenal Cushing's syndrome. We define mechanisms of action for the PKAc-L205R …

This review describes the molecular alterations observed in the various types of tumors of
the adrenal cortex, excluding Conn adenomas, especially the alterations identified by …

Mild hypercortisolism is defined as biochemical evidence of abnormal cortisol secretion
without the classical detectable manifestations of overt Cushing's syndrome and, above all …

Aldosterone and cortisol serve important roles in the pathogenesis of cardiovascular
diseases and metabolic disorders. Epigenetics is a mechanism to control enzyme …

Resident progenitor and/or stem cell populations in the adult adrenal cortex enable cortical
cells to undergo homeostatic renewal and regeneration after injury. Renewal occurs …