The neuromuscular junction (NMJ) is a highly specialized synapse between a motor neuron
nerve terminal and its muscle fiber that are responsible for converting electrical impulses …

Maturation of neuronal circuits requires selective elimination of synaptic connections.
Although neuron-intrinsic mechanisms are important in this process, it is increasingly …

Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory,
perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed …

Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …

Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor
in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the …

Phagocytic activity of glial cells is essential for proper nervous system sculpting,
maintenance of circuitry, and long-term brain health. Glial engulfment of apoptotic cells and …

Myelination is essential for central nervous system (CNS) formation, health, and function.
Emerging evidence of oligodendrocyte heterogeneity in health and disease and divergent …

The neuromuscular junction (NMJ) is a tripartite synapse that is formed by motor nerve
terminals, postjunctional muscle membranes, and terminal Schwann cells (TSCs) that cover …

The mammalian neuromuscular junction (NMJ) comprises a presynaptic terminal, a
postsynaptic receptor region on the muscle fiber (endplate), and the perisynaptic (terminal) …

Action potential propagation along myelinated axons depends on the geometry of the myelin
unit and the division of the underlying axon to specialized domains. The latter include the …