The 17β-hydroxysteroid dehydrogenases (17β-HSDs) play an important role in the
regulation of steroid hormones, such as estrogens and androgens, by catalysing the …

17β-Hydroxysteroid dehydrogenases (17β-HSDs) catalyze the NAD (P)(H) dependent
oxidoreduction at C17 oxo/β-hydroxyl groups of androgen and estrogen hormones. This …

In women and men, an important proportion of estrogens and androgens are synthesized
locally at their site of action in peripheral target tissues. This new field of endocrinology has …

Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit
receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary …

In postmenopausal women, almost 100% of active sex steroids are synthesized in
peripheral target tissues from inactive steroid precursors and, in adult men, approximately …

At the late 1940s, 17β-HSD1 was discovered as the first member of the 17β-HSD family with
its gene cloned. The three-dimensional structure of human 17β-HSD1 is the first example of …

Diabetes is a predominant metabolic disease nowadays due to the off‐beam lifestyle of diet
and reduced physical activity. Complications of the illness include the gene‐environment …

Oestradiol is a well-characterized sex hormone that stimulates breast cancer and other
oestrogen-related diseases. 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) …

Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit
receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary …

In order to elucidate the roles of 17β-HSDs in fish gonadal steroidogenesis, three types of
17β-HSDs (17β-HSD1, 17β-HSD8 and putative 17β-HSD12) were cloned and characterized …