Blood GFAP as an emerging biomarker in brain and spinal cord disorders

A Abdelhak, M Foschi, S Abu-Rumeileh… - Nature Reviews …, 2022 - nature.com
Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of …

Traumatic brain injuries

K Blennow, DL Brody, PM Kochanek, H Levin… - Nature reviews Disease …, 2016 - nature.com
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19

N Kanberg, NJ Ashton, LM Andersson, A Yilmaz… - Neurology, 2020 - AAN Enterprises
Objective To test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …

Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up

N Kanberg, J Simrén, A Edén, LM Andersson… - …, 2021 - thelancet.com
Background Neurologic manifestations are well-recognized features of coronavirus disease
2019 (COVID-19). However, the longitudinal association of biomarkers reflecting CNS …

Blood biomarkers on admission in acute traumatic brain injury: relations to severity, CT findings and care path in the CENTER-TBI study

E Czeiter, K Amrein, BY Gravesteijn, F Lecky… - …, 2020 - thelancet.com
Background Serum biomarkers may inform and improve care in traumatic brain injury (TBI).
We aimed to correlate serum biomarkers with clinical severity, care path and imaging …

Assessing the clinical impact of risk prediction models with decision curves: guidance for correct interpretation and appropriate use

KF Kerr, MD Brown, K Zhu, H Janes - Journal of Clinical Oncology, 2016 - ascopubs.org
The decision curve is a graphical summary recently proposed for assessing the potential
clinical impact of risk prediction biomarkers or risk models for recommending treatment or …

Plasma markers of neurologic injury and inflammation in people with self-reported neurologic postacute sequelae of SARS-CoV-2 infection

MJ Peluso, HM Sans, CA Forman… - Neurology …, 2022 - AAN Enterprises
Background and Objectives The biologic mechanisms underlying neurologic postacute
sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective …

JK Yue, EL Yuh, FK Korley, EA Winkler, X Sun… - The Lancet …, 2019 - thelancet.com
Background After traumatic brain injury (TBI), plasma concentration of glial fibrillary acidic
protein (GFAP) correlates with intracranial injury visible on CT scan. Some patients with …

Fluid biomarkers for mild traumatic brain injury and related conditions

H Zetterberg, K Blennow - Nature reviews neurology, 2016 - nature.com
Diagnostic and prognostic biomarkers for mild traumatic brain injury (TBI), also known as
concussion, remain a major unmet clinical need. Moderate to severe TBI can be diagnosed …

Blood biomarkers for traumatic brain injury: a quantitative assessment of diagnostic and prognostic accuracy

ZS Gan, SC Stein, R Swanson, S Guan… - Frontiers in …, 2019 - frontiersin.org
Blood biomarkers have been explored for their potential to provide objective measures in
the assessment of traumatic brain injury (TBI). However, it is not clear which biomarkers are …