Genetic testing has been applied for decades in clinical routine diagnostics of hematological
malignancies to improve disease (sub) classification, prognostication, patient management …

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by genetic
alterations with high heterogeneity. Precise subtypes with distinct genomic and/or gene …

The current classification of acute myeloid leukemia (AML) relies largely on genomic
alterations. Robust identification of clinically and biologically relevant molecular subtypes …

Fusion genes (FGs) are important genetic abnormalities in acute leukemias, but their variety
and occurrence in acute leukemias remain to be systematically described. Whole …

PURPOSE Optimized strategies for risk classification are essential to tailor therapy for
patients with biologically distinctive disease. Risk classification in pediatric acute myeloid …

Fusion transcripts are frequent genetic abnormalities in myeloid malignancies and are often
the basis for risk stratification, minimal residual disease (MRD) monitoring, and targeted …

Background Considering the clinical and genetic characteristics, acute lymphoblastic
leukemia (ALL) is a rather heterogeneous hematological neoplasm for which current …

Precision medicine is revolutionising patient care in cancer. As more knowledge is gained
about the impact of specific genetic lesions on diagnosis, prognosis and treatment response …

Identification of fusion genes in clinical routine is mostly based on cytogenetics and targeted
molecular genetics, such as metaphase karyotyping, fluorescence in situ hybridization and …

Simple Summary NUP98-NSD1-positive acute myeloid leukemia (AML) frequently shows an
additional mutation in Neuroblastoma rat sarcoma (NRAS). However, the synergistic effect of …