Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response
The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …
despite decades of research. In this paper, we make three major claims. First, serotonin …
[HTML][HTML] Understanding stress: Insights from rodent models
Through incorporating both physical and psychological forms of stressors, a variety of rodent
models have provided important insights into the understanding of stress physiology …
models have provided important insights into the understanding of stress physiology …
Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression
Depressive disorders, including major depression, are serious and disabling. However, the
exact pathophysiology of depression is not clearly understood. Life stressors contribute in …
exact pathophysiology of depression is not clearly understood. Life stressors contribute in …
Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress
Stress plays a key role in the induction of various clinical disorders by altering
monoaminergic response and antioxidant defenses. In the present study, alterations in the …
monoaminergic response and antioxidant defenses. In the present study, alterations in the …
Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1
BACKGROUND: Many studies link depression to an increase in the excitatory–inhibitory
ratio in the forebrain. Presynaptic alterations in a shared pathway of the glutamate/gamma …
ratio in the forebrain. Presynaptic alterations in a shared pathway of the glutamate/gamma …
Brain glucose metabolism in an animal model of depression
J Detka, A Kurek, M Kucharczyk, K Głombik… - Neuroscience, 2015 - Elsevier
An increasing number of data support the involvement of disturbances in glucose
metabolism in the pathogenesis of depression. We previously reported that glucose and …
metabolism in the pathogenesis of depression. We previously reported that glucose and …
Chronic unpredictable stress negatively regulates hippocampal neurogenesis and promote anxious depression-like behavior via upregulating apoptosis and …
Psychological and physical stress play a pivotal role in etiology of anxiety and depression.
Chronic psychological and physical stress modify various physiological phenomena, as a …
Chronic psychological and physical stress modify various physiological phenomena, as a …
Effect of chronic stress on behavior and cerebral oxidative metabolism in rats with high or low positive affect
The 50 kHz ultrasonic vocalizations (USVs) in rats have been associated with positive affect
and rewarding experience. We have previously reported that stable inter-individual …
and rewarding experience. We have previously reported that stable inter-individual …
Brain responses to chronic social defeat stress: effects on regional oxidative metabolism as a function of a hedonic trait, and gene expression in susceptible and …
Chronic social defeat stress, a depression model in rats, reduced struggling in the forced
swimming test dependent on a hedonic trait-stressed rats with high sucrose intake struggled …
swimming test dependent on a hedonic trait-stressed rats with high sucrose intake struggled …
[HTML][HTML] Acute administration of ketamine reverses the inhibition of mitochondrial respiratory chain induced by chronic mild stress
GT Rezin, CL Gonçalves, JF Daufenbach, DB Fraga… - Brain research …, 2009 - Elsevier
Modulation and dysfunction of the glutamatergic system seems to be involved in depression.
Recently a renewed interest in the glutamatergic system as a treatment option for major …
Recently a renewed interest in the glutamatergic system as a treatment option for major …