Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …
made it challenging to address questions that are specific to the understanding of human …
Regulation, functions and transmission of bivalent chromatin during mammalian development
TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …
landscape that mediates gene expression programmes. During development, mammalian …
[HTML][HTML] Complete human day 14 post-implantation embryo models from naive ES cells
The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …
and technical challenges associated with intrauterine development after implantation …
[HTML][HTML] Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs
In vitro cultured stem cells with distinct developmental capacities can contribute to
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …
Self-patterning of human stem cells into post-implantation lineages
Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …
and ethical limitations of working with embryonic samples. In the face of these difficulties …
Rolling back human pluripotent stem cells to an eight-cell embryo-like stage
After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …
a short-lived totipotent state. Understanding the process of totipotency in human cells would …
Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis
The mammalian body plan is established shortly after the embryo implants into the maternal
uterus, and our understanding of post-implantation developmental processes remains …
uterus, and our understanding of post-implantation developmental processes remains …
Advances in pluripotent stem cells: history, mechanisms, technologies, and applications
G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …
milestones have driven basic, translational, and clinical advances in the field of stem cell …
Mammalian in vitro gametogenesis
M Saitou, K Hayashi - Science, 2021 - science.org
BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …
Cynomolgus monkey embryo model captures gastrulation and early pregnancy
J Li, Q Zhu, J Cao, Y Liu, Y Lu, Y Sun, Q Li, Y Huang… - Cell Stem Cell, 2023 - cell.com
Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …
blastocysts. However, the ability to investigate their developmental potential is limited. Here …