The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …

Alternative splicing is one of the most important mechanisms to generate a large number of
mRNA and protein isoforms from the surprisingly low number of human genes. Unlike …

Abstract The Wilms' tumor 1 (WT1) gene encodes a transcription factor important for normal
cellular development and cell survival. The initial discovery of WT1 as the causative gene in …

The Wilms' tumor 1 gene (WT1) has been identified as a tumor suppressor gene involved in
the etiology of Wilms' tumor. Approximately 10% of all Wilms' tumors carry mutations in the …

Despite 12 yr since the discovery of SRY, little is known at the molecular level about how
SRY and the SRY-related protein, SOX9 [SRY-related high-mobility group (HMG) box 9] …

The WT1 (Wilms' tumour 1) gene encodes a zinc finger transcription factor and RNA-binding
protein that direct the development of several organs and tissues. WT1 manifests both …

Promyelocytic leukemia (PML) nuclear bodies (PML NBs) are discrete subnuclear domains
organized by the promyelocytic leukemia protein PML, a tumor suppressor essential for …

The Wilms' tumour gene, WT1, encodes a zinc-finger transcription factor that is inactivated in
a subset of Wilms' tumours. Mutation analysis in human patients and genetic experiments in …

The past decade has witnessed substantial growth in our knowledge of the genes and loci
that are altered in Wilms tumor. Although Wilms tumor was one of the original paradigms of …

Prostate apoptosis response-4 (par-4) is a pro-apoptotic gene identified in prostate cancer
cells undergoing apoptosis. Par-4 protein, which contains a leucine zipper domain at the …