RING finger domain and RING finger-like ubiquitin ligases (E3s), such as U-box proteins,
constitute the vast majority of known E3s. RING-type E3s function together with ubiquitin …

Mass-spectrometry based proteomics has evolved as a promising technology over the last
decade and is undergoing a dramatic development in a number of different areas, such as; …

After more than a decade of method development, cross-linking in combination with mass
spectrometry and bioinformatics is finally coming of age. This technology now provides …

Chemical cross-linking of reactive groups in native proteins and protein complexes in
combination with the identification of cross-linked sites by mass spectrometry has been in …

Closely related to studying the function of a protein is the analysis of its three‐dimensional
structure and the identification of interaction sites with its binding partners. An alternative …

Serum albumin is the principal transporter of fatty acids that are otherwise insoluble in
circulating plasma. While the crystal structure of human serum albumin (HSA) as well as its …

The advent of soft-ionization mass spectrometry for biomolecules has opened up new
possibilities for the structural analysis of proteins. Combining protein chemistry methods with …

Chemical cross‐linking of proteins, an established method in protein chemistry, has gained
renewed interest in combination with mass spectrometric analysis of the reaction products …

Chemical cross-linking combined with a subsequent enzymatic cleavage of the created
cross-linked complex and a mass spectrometric analysis of the resulting cross-linked …

The growth of gene and protein sequence information is currently so rapid that three-
dimensional structural information is lacking for the overwhelming majority of known …