Converging research efforts suggest that nicotine and other drugs that act at nicotinic
acetylcholine receptors (nAChRs) may be beneficial in the management of Parkinson's …

Epidemiological studies show that smoking is associated with a lower incidence of
Parkinson's disease (PD). This finding is important because it could provide clues about …

Exposure of rats to the pesticide and complex I inhibitor rotenone reproduces features of
Parkinson's disease, including selective nigrostriatal dopaminergic degeneration and α …

Almost all degenerative diseases of the CNS are associated with chronic inflammation. A
central step in this process is the activation of brain mononuclear phagocyte cells, called …

Parkinson's disease (PD) has been linked to mitochondrial dysfunction and pesticide
exposure. The pesticide rotenone (ROT) inhibits complex I and reproduces features of PD in …

Background: Catalase catalyzes the reduction of H2O2 to water and it can also remove
organic hydroperoxides. Nervous system in body is especially sensitive to free radical …

Imidacloprid is the most important example of the neonicotinoid insecticides known to target
the nicotinic acetylcholine receptor (nAChR) in insects, and potentially in mammals. In the …

Evidence obtained over the past two decades shows that reactive oxygen species (ROS) are
involved in brain lesions, including those due to cerebral ischemia-reperfusion. The …

Mitochondria are multifunctional and dynamic organelles deeply integrated into cellular
physiology and metabolism. Disturbances in mitochondrial function are involved in several …

Many studies have focused on expanding our knowledge of the structure and diversity of
peripheral and central nicotinic receptors. Nicotinic acetylcholine receptors (nAChRs) are …