Metabolomics in diabetes and diabetic complications: insights from epidemiological studies
Q Jin, RCW Ma - Cells, 2021 - mdpi.com
The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …
kidney disease, remains a huge burden globally. Identification of biomarkers for the …
[HTML][HTML] Pathophysiologic mechanisms and potential biomarkers in diabetic kidney disease
CY Jung, TH Yoo - Diabetes & Metabolism Journal, 2022 - synapse.koreamed.org
Although diabetic kidney disease (DKD) remains the leading cause of end-stage kidney
disease eventually requiring chronic kidney replacement therapy, the prevalence of DKD …
disease eventually requiring chronic kidney replacement therapy, the prevalence of DKD …
Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
A Nakamura, S Kurihara, D Takahashi… - Nature …, 2021 - nature.com
Intestinal microbiota-derived metabolites have biological importance for the host.
Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota …
Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota …
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis
V Miguel, J Tituaña, JI Herrero… - The Journal of …, 2021 - Am Soc Clin Investig
Chronic kidney disease (CKD) remains a major epidemiological, clinical, and biomedical
challenge. During CKD, renal tubular epithelial cells (TECs) present a persistent …
challenge. During CKD, renal tubular epithelial cells (TECs) present a persistent …
Metabolomics for clinical use and research in chronic kidney disease
B Hocher, J Adamski - Nature Reviews Nephrology, 2017 - nature.com
Chronic kidney disease (CKD) has a high prevalence in the general population and is
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …
Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota
The involvement of host immunity in the gut microbiota-mediated colonization resistance to
Clostridioides difficile infection (CDI) is incompletely understood. Here, we show that …
Clostridioides difficile infection (CDI) is incompletely understood. Here, we show that …
Measurement of DNA concentration as a normalization strategy for metabolomic data from adherent cell lines
Metabolomics is a rapidly advancing field, and much of our understanding of the subject has
come from research on cell lines. However, the results and interpretation of such studies …
come from research on cell lines. However, the results and interpretation of such studies …
Biomarkers of diabetic kidney disease
HM Colhoun, ML Marcovecchio - Diabetologia, 2018 - Springer
Diabetic kidney disease (DKD) remains one of the leading causes of reduced lifespan in
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …
Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease
PR Pereira, DF Carrageta, PF Oliveira… - Medicinal Research …, 2022 - Wiley Online Library
Diabetic kidney disease (DKD) is one of the most prevalent comorbidities of diabetes
mellitus and the leading cause of the end‐stage renal disease (ESRD). DKD results from …
mellitus and the leading cause of the end‐stage renal disease (ESRD). DKD results from …
Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens
The high susceptibility of neonates to infections has been assumed to be due to immaturity
of the immune system, but the mechanism remains unclear. By colonizing adult germ-free …
of the immune system, but the mechanism remains unclear. By colonizing adult germ-free …