P-21 activated kinases, or PAKs, are serine–threonine kinases that serve a role in diverse
biological functions and organ system diseases. Although PAK signaling has been the focus …

PAK1 kinase is a crucial regulator of a variety of cellular processes, such as motility, cell
division, gene transcription and apoptosis. Its deregulation is involved in several …

Abstract The Protein Structure Initiative (PSI) was established in 2000 by the National
Institutes of General Medical Sciences with the long-term goal of providing 3D (three …

Abstract Mixed lineage kinase 3 (MLK3), a MAP3K member has been envisioned as a viable
drug target in cancer, yet its detailed function and signaling is not fully elucidated. We …

Mycobacterium tuberculosis harbors over 160 genes encoding PE/PPE proteins, several of
which have roles in the pathogen's virulence. A number of PE/PPE proteins are secreted via …

Highlights•Many computationally designed protein–protein interactions were reported over
the past two years.•Recent design goals include heterodimers, homodimers …

Six human PAK members are classified into groups I (PAKs 1–3) and II (PAK4–6).
Previously, only group I PAKs were thought to be auto-inhibited but very recently PAK4, the …

The p21-activated kinase (PAK) family plays a versatile role in cell signaling by forming a
hub of interactions. PAKs bind the GTPases like RAC and CDC42. Their proline-rich motifs …

This thesis aims to investigate the form-phase diagram of aqueous solutions of the triblock
copolymer Pluronic P123 focusing on its high-temperature phases. P123 is based on …

P21-activated kinase (PAK1), a serine/threonine protein kinase, has significant homeostatic
functions in the myocardium. PAK1's activation of protective signaling in cardiac pathways …