Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

When vertebrate cells exit mitosis various cellular structures are re-organized to build
functional interphase cells. This depends on Cdk1 (cyclin dependent kinase 1) inactivation …

The mitosis-to-interphase transition involves dramatic cellular reorganization from a state
that supports chromosome segregation to a state that complies with all functions of an …

Entry into mitosis depends on the activity of cyclin‐dependent kinases (CDKs). Conversely,
exit from mitosis occurs when mitotic cyclins are degraded, thereby extinguishing CDK …

Loss of cell division cycle 2 (Cdc2, also known as Cdk1) activity after cyclin B degradation is
necessary, but not sufficient, for mitotic exit. Proteins phosphorylated by Cdc2 and …

Progression through the cell cycle is controlled by regulated and abrupt changes in
phosphorylation. Mitotic entry is initiated by increased phosphorylation of mitotic proteins, a …

Repo-Man targets protein phosphatase 1 γ (PP1γ) to chromatin at anaphase onset and
regulates chromosome structure during mitotic exit. Here, we show that a Repo-Man: PP1 …

Targeting mitotic exit has been recently proposed as a relevant therapeutic approach
against cancer. By using genetically engineered mice, we show that the APC/C cofactor …