Gene therapy is becoming an increasingly valuable tool to treat many genetic diseases with
no or limited treatment options. This is the case for hundreds of monogenic metabolic …

There is increasing incidence and prevalence of acute and chronic liver diseases (CLDs) all
over the world which influence the quality of life and can give rise to life threatening …

Owing to retained hepatic phenotypes and functions, human three-dimensional (3D) hepatic
models established with diverse hepatic cell types are thought to recoup the gaps in drug …

CRISPR/Cas12a (Cpf1) is a single RNA-guided endonuclease that provides new
opportunities for targeted genome engineering through the CRISPR/Cas9 system. Only …

The use of biomaterials in delivering CRISPR/Cas9 for gene therapy in infectious diseases
holds tremendous potential. This innovative approach combines the advantages of …

Non-alcoholic fatty liver disease (NAFLD) afflicts a significant percentage of the population;
however, no effective treatments have yet been established because of the unsuitability of in …

The bile salt export pump (BSEP/ABCB11) is responsible for the transport of bile salts from
hepatocytes into bile canaliculi. Malfunction of this transporter results in progressive familial …

Serving as the metabolic hub of the human body, the liver is a vital organ that performs a
variety of important physiological functions. Although known for its regenerative potential, it …

The resistance of multidrug-resistant bacteria to existing antibiotics forces the continued
development of new antibiotics and antibacterial agents, but the high costs and long …

Human genetic disorders, arising from a range of genetic irregularities, can significantly
affect human physiology, often with limited available treatment options. The development of …