Overweight and obesity have become a world-wide problem. However, effective intervention
approaches are limited. Brown adipose tissue, which helps maintain body temperature and …

Protein kinases represent a very pharmacologically attractive class of targets; however,
some members of the family still remain rather unexplored. The biology and therapeutic …

Background Intermittent fasting is a popular dietary intervention with perceived relatively
easy compliance and is linked to various health benefits, including weight loss and …

The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour
suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly …

Obesity, one of the most serious public health issues, is caused by the imbalance of energy
intake and energy expenditure. N (6)-methyladenosine (m6A) RNA modification has been …

Summary Background Benefits of Intermittent fasting (IF) on health-related outcomes have
been found in a range of randomised controlled trials (RCTs). Our umbrella review aimed to …

Intermittent fasting (IF) is a widely practiced dietary method that encompasses periodic
restriction of food consumption. Due to its protective benefits against metabolic diseases …

Historically, intermittent fasting (IF) has been considered as an effective strategy for
controlling the weight of athletes before competition. Along with excellent insight into its …

Dysregulation of alternative splicing is a feature of cancer, both in aetiology and
progression. It occurs because of mutations in splice sites or sites that regulate splicing, or …

The global prevalence of metabolic disorders, such as obesity, diabetes and fatty liver
disease, is dramatically increasing. Both genetic and environmental factors are well-known …