Synthesis of Anticoagulant Pentasaccharide Fondaparinux via 3, 5-Dimethyl-4-(2′-phenylethynylphenyl) phenyl Glycosides

W Liu, Z Hu, P Xu, B Yu - Organic Letters, 2023 - ACS Publications
Here, we disclosed a convenient procedure for the preparation of EPP [3, 5-dimethyl-4-(2′-
phenylethynylphenyl) phenyl] glycosides and their application to an effective synthesis of …

Design and synthesis of neutralizable fondaparinux

L Zhang, Y Liu, Z Xu, T Hao, PG Wang, W Zhao, T Li - JACS Au, 2022 - ACS Publications
Fondaparinux, a clinically approved anticoagulant pentasaccharide for the treatment of
thrombotic diseases, displays better efficacy and biosafety than other heparin-based …

Overview of the current procedures in synthesis of heparin saccharides

S Zhao, T Zhang, Y Kan, H Li, J Li - Carbohydrate Polymers, 2024 - Elsevier
Natural heparin, a glycosaminoglycan consisting of repeating hexuronic acid and
glucosamine linked by 1→ 4 glycosidic bonds, is the most widely used anticoagulant. To …

Gold catalysis in organic synthesis: fifteen years of research in India

D Mandal, A Kumar, NT Patil - Proceedings of the Indian National Science …, 2022 - Springer
Gold catalysis has emerged as an important tool in the field of synthetic organic chemistry for
the selective functionalization of C–C multiple bonds. The research in India on gold catalysis …

Cut-insert-stitch editing reaction (CIStER) sequence for surgical chemical glycan editing

S Sen, S Kundu, S Pasari, S Hotha - Communications Chemistry, 2024 - nature.com
Post-synthetic surgical editing enables synthesizing diverse molecules from a common
scaffold. Editing carbohydrates by inserting a foreign glycan is still a far-reaching goal for …

Synthesis of Four Orthogonally Protected Rare l-Hexose Thioglycosides from d-Mannose by C-5 and C-4 Epimerization

F Demeter, I Bereczki, A Borbás, M Herczeg - Molecules, 2022 - mdpi.com
l-Hexoses are important components of biologically relevant compounds and precursors of
some therapeuticals. However, they typically cannot be obtained from natural sources and …

Synthesis of L‐Hexoses: An Update

A Paul, SS Kulkarni - The Chemical Record, 2021 - Wiley Online Library
Over the years, carbohydrates have increasingly become an important class of compounds
contributing significantly to the target specific drug discovery and vaccine development …

Tailor-made glycans

S Kim, GA O'Doherty - Nature Reviews Chemistry, 2024 - nature.com
A highly chemoselective method for the insertion of carbohydrates into existing
oligosaccharides has been developed. The reaction sequence involves a selective Lewis …

Glycosyl Vinylogous Carbonates as Glycosyl Donors by Metal-Free Activation

N Kasdekar, G Walke, K Deshpande… - The Journal of Organic …, 2022 - ACS Publications
Synthesis of glycoconjugates employs a glycosylation reaction wherein an electrophile and
a nucleophile known as a glycosyl donor and an aglycon, respectively, are involved …

Recent advances in the radiation chemistry of destructured starch and other glucans as model compounds

D Khandal, S Fatahiyah Mohamad, X Coqueret - 2021 - books.rsc.org
This chapter overviews the influence of radiation processing applied to thermoplastic starch
and some other glucans in blends prepared with various types of plasticizers and additives …