Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

Liver cirrhosis is a major cause of death worldwide and is characterized by extensive
fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better …

Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their
inherent ability to bind and internalize a wide array of structurally diverse ligands which can …

Atherosclerosis is the predominant underlying pathology of many types of cardiovascular
disease and is one of the leading causes of death worldwide. It is characterized by the …

Background As is a prerequisite of belonging to the scavenger receptor super family,
SCARF1 (scavenger receptor class F, member 1) is known to play a key role in the binding …

Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic
liver disease (CLD), and yet the factors that drive this process and the impact on their …

The scavenger receptor superfamily represents a highly diverse collection of evolutionarily-
conserved receptors which are known to play key roles in host homeostasis, the most …

The 17p13. 3 chromosome region is often deleted or duplicated in humans, resulting in
severe neurodevelopmental disorders such as Miller–Dieker syndrome (MDS) and 17p13. 3 …

Between 30 and 50% of the world population is permanently colonized in some anatomical
site by Staphylococcus aureus, although the vast majority are asymptomatic carriers. The …

Deficiency in the clearance of cellular debris is a major pathogenic factor in the emergence
of autoimmune diseases. We previously demonstrated that mice deficient for scavenger …