As a potent chemotherapeutic agent, doxorubicin (DOX) is widely used for the treatment of a
variety of cancers However, its clinical utility is limited by dose-dependent cardiotoxicity, and …

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

It was a surprising discovery when mitochondria, as the power houses of cells, were also
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …

Purpose Doxorubicin, as an effective chemotherapeutic drug, is commonly used for
combating various solid and hematological tumors. However, doxorubicin-induced …

Doxorubicin (DOX) is an anthracycline chemotherapy drug used in the treatment of various
types of cancer. However, short-term and long-term cardiotoxicity limits the clinical …

Doxorubicin (DOX) is an anticancer medicine that may trigger cardiomyopathy. Rosmarinic
acid (RA) has shown antioxidant, anti-inflammatory, and anticancer effects. This …

Cardiotoxicity is the major side effect of anthracyclines (doxorubicin, daunorubicin,
epirubicin, and idarubicin), though being the most commonly used chemotherapy drugs and …

Mitochondria are organelles that play a pivotal role in the production of energy in cells, and
vital to the maintenance of cellular homeostasis due to the regulation of many biochemical …

Simple Summary The use of date palm pollen ethanolic extract (DPPE) is a conventional
approach in improving the side-effects induced by Doxorubicin (DOX). DPPE mitigated DOX …

Doxorubicin is a potent chemotherapeutic drug; however, its clinical application has been
limited due to its cardiotoxicity. One of the major mechanisms of doxorubicin-induced …